Seroatlas · Human Serome Atlas

AGBL3

Cytosolic carboxypeptidase 3

Also known as: CBPC3_HUMAN, CCP3, MGC32955

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEM8
Gene: AGBL3
Ensembl: ENSG00000146856
Chromosome: 7
Canonical length: 1001 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Predicted to be located in cytosol. Predicted to be active in centriole and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1001 residues, UniProt reviewed canonical sequence.

>Q8NEM8|AGBL3
     1  MSEDSEKEDY SDRTISDEDE SDEDMFMKFV SEDLHRCALL TADSFGDPFF PRTTQILLEY
    61  QLGRWVPRLR EPRDLYGVSS SGPLSPTRWP YHCEVIDEKV QHIDWTPSCP EPVYIPTGLE
   121  TEPLYPDSKE ATVVYLAEDA YKEPCFVYSR VGGNRTPLKQ PVDYRDNTLM FEARFESGNL
   181  QKVVKVAEYE YQLTVRPDLF TNKHTQWYYF QVTNMRAGIV YRFTIVNFTK PASLYSRGMR
   241  PLFYSEKEAK AHHIGWQRIG DQIKYYRNNP GQDGRHYFSL TWTFQFPHNK DTCYFAHCYP
   301  YTYTNLQEYL SGINNDPVRS KFCKIRVLCH TLARNMVYIL TITTPLKNSD SRKRKAVILT
   361  ARVHPGETNS SWIMKGFLDY ILGNSSDAQL LRDTFVFKVV PMLNPDGVIV GNYRCSLAGR
   421  DLNRNYTSLL KESFPSVWYT RNMVHRLMEK REVILYCDLH GHSRKENIFM YGCDGSDRSK
   481  TLYLQQRIFP LMLSKNCPDK FSFSACKFNV QKSKEGTGRV VMWKMGIRNS FTMEATFCGS
   541  TLGNKRGTHF STKDLESMGY HFCDSLLDYC DPDRTKYYRC LKELEEMERH ITLEKVFEDS
   601  DTPVIDITLD VESSSRGSDS SESIDSLTYL LKLTSQKKHL KTKKERNSTI ASHQNARGQE
   661  VYDRGHLLQR HTQSNSDVKD TRPNEPDDYM VDYFRRQLPN QGLAHCKLRL PGSRHSPASA
   721  SRVAGTTGTR HHTWLIFVFL VEMGKKIPLK GTDLYGNCFK VTSLQSPMGK QTSTWTEKTR
   781  IPTEDLHHNL KSKIKECISF QSKKTGINWT DDEKRSYKDK GIVQTQEILQ YLLPIVHSTK
   841  NMQTTQIKQL FNPRTNFQIQ HQLNPATCRN IKKYSTSWTA PRNHPFVIQG DVMANSSEWV
   901  QSKPHRSLES LSPLKGPKKN KHSQIWAIKN EDIKPLSSKW ETASSSFGMD ANVLKYKSLQ
   961  AEETNQQSSK HTALHLTKNK DEQANKNDGQ PTLYLKFQRE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGBL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 7.4 nTPM

Expression across tissuesHPA

Tissue

epididymis: 7.4 nTPM
testis: 4.7 nTPM
spleen: 3.5 nTPM
endometrium: 2.7 nTPM
thyroid gland: 2.6 nTPM
salivary gland: 2.4 nTPM

Single-cell type

cardiomyocytes: 277 nCPM
late primary spermatocytes: 170 nCPM
early spermatids: 155 nCPM
myonuclei: 131 nCPM
adipocytes: 129 nCPM
ependymal cells: 120 nCPM

Immune cell

naive CD8 T-cell: 1.7 nTPM
memory CD8 T-cell: 0.9 nTPM
NK-cell: 0.9 nTPM
gdT-cell: 0.8 nTPM
memory B-cell: 0.8 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

cerebellum: 5.1 nTPM
hypothalamus: 4.9 nTPM
white matter: 4.5 nTPM
cerebral cortex: 4.4 nTPM
spinal cord: 3.8 nTPM
basal ganglia: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.92
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGBL3 as an antibody target. Whether an autoantibody or antibody against AGBL3 could matter depends on whether native AGBL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGBL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGBL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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