Seroatlas · Human Serome Atlas

AGAP6

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6

Also known as: AGAP6_HUMAN, bA324H6.1, CTGLF3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VW22
Gene: AGAP6
Ensembl: ENSG00000204149
Chromosome: 10
Canonical length: 663 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q5VW22|AGAP6
     1  MGNILTCRVH PSVSLEFDQQ QGSVCPSESE TYEAGARDRM AGAPMAAAVQ PAEVTVEVGE
    61  DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV SAVRFSQQYS
   121  LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRT LSIPDEQLHS FAVSTVHIMK
   181  KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD
   241  KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGML TYYSSLGDYM
   301  KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISSSKSNGL SKDMDTGLGD SICFSPSISS
   361  TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL
   421  ASLQSCESSK SKSQLTSQSE AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS
   481  GIHRSLGPHL SRVRSLELDD WPVELRKVMS SIVNDLANSI WEGSSQGQTK PSEKSTREEK
   541  ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSCE EVNETCGEGD
   601  GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD
   661  ECV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 22 nTPM
spleen: 22 nTPM
liver: 21 nTPM
cerebellum: 21 nTPM
thyroid gland: 18 nTPM
prostate: 17 nTPM

Single-cell type

distal convoluted tubule cells: 48 nCPM
podocytes: 40 nCPM
proximal tubule cells: 40 nCPM
renal connecting tubule cells: 37 nCPM
renal collecting duct intercalated cells: 34 nCPM
loop of henle epithelial cells: 31 nCPM

Immune cell

basophil: 1.3 nTPM
NK-cell: 0.8 nTPM
naive CD4 T-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

choroid plexus: 7.8 nTPM
cerebellum: 7.1 nTPM
white matter: 6.3 nTPM
cerebral cortex: 5.9 nTPM
thalamus: 5.5 nTPM
amygdala: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -1.09
DepMap mean gene effect: -0.5
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP6 as an antibody target. Whether an autoantibody or antibody against AGAP6 could matter depends on whether native AGAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...