Seroatlas · Human Serome Atlas

AGAP5

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5

Also known as: AGAP5_HUMAN, CTGLF2, Em:AC073389.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIR3
Gene: AGAP5
Ensembl: ENSG00000172650
Chromosome: 10
Canonical length: 686 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>A6NIR3|AGAP5
     1  MGNILTCCVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE
    61  DLHMHHIRDQ EMPEALEFSL SANPEASTIF QRNSQTDALE FNPSANPEAS TIFQRNSQTD
   121  VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTASQHYL TMTIISVTLE IPHHITQRDA
   181  DRSLSIPDEQ LHSFAVSTVH ITKNRNGGGS LNNYSSSIPS TPSTSQEDPQ FSVPPTANTP
   241  TPVCKRSMRW SNLFTSEKGS HPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW
   301  KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS
   361  NGLSKDMDTG LGDSICFSPS ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT
   421  WHFEATTYEE RDAWVQAIQS QILASLQSCE SSKSKSQLTS QSEAMALQSI QNMRGNAHCV
   481  DYETQNPKWA SLNLGVLMCI ECSGIHRSLG TRLSRVRSLE LDDWPVELRK VMSSIGNDLA
   541  NSIWEGSSQG QTKPSVKSTR EEKERWIRSK YEEKLFLAPL PCTELSLGQH LLRATADEDL
   601  QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLA QLLIWYGVDV MARDAHGNTA
   661  LTYARQASSQ ECINVLLQYG CPDECV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

pancreas: 14 nTPM
testis: 13 nTPM
liver: 9.7 nTPM
pituitary gland: 8 nTPM
skeletal muscle: 7.8 nTPM
adrenal gland: 7.2 nTPM

Single-cell type

microglia: 19 nCPM
proximal tubule cells: 17 nCPM
distal convoluted tubule cells: 16 nCPM
loop of henle epithelial cells: 15 nCPM
choroid plexus epithelial cells: 14 nCPM
podocytes: 14 nCPM

Immune cell

basophil: 0.6 nTPM
gdT-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

choroid plexus: 10 nTPM
white matter: 10 nTPM
cerebellum: 9.9 nTPM
thalamus: 8.3 nTPM
cerebral cortex: 8.2 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0.01
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.58
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP5 as an antibody target. Whether an autoantibody or antibody against AGAP5 could matter depends on whether native AGAP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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