Seroatlas · Human Serome Atlas

AGAP4

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Also known as: AGAP4_HUMAN, AGAP8, CTGLF1, CTGLF5, Em:AC012044.1, MRIP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P64
Gene: AGAP4
Ensembl: ENSG00000188234
Chromosome: 10
Canonical length: 663 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity and GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q96P64|AGAP4
     1  MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAGDRM AGAPMAAAVQ PAEVTVEVGE
    61  DLHMHHVRDR EMPEALEFNP SANPEASTIF QRNSQTDVVE IRRSNCTNHV STVRFSQQYS
   121  LCSTIFLDDS TAIQHYLTMT IISVTLEIPH HITQRDADRS LSIPDEQLHS FAVSTVHIMK
   181  KRNGGGSLNN YSSSIPSTPS TSQEDPQFSV PPTANTPTPV CKRSMRWSNL FTSEKGSDPD
   241  KERKAPENHA DTIGSGRAIP IKQGMLLKRS GKWLKTWKKK YVTLCSNGVL TYYSSLGDYM
   301  KNIHKKEIDL QTSTIKVPGK WPSLATSACT PISTSKSNGL SKDMDTGLGD SICFSPSISS
   361  TTSPKLNPPP SPHANKKKHL KKKSTNNFMI VSATGQTWHF EATTYEERDA WVQAIQSQIL
   421  ASLQSCESSK SKSQLTSQSK AMALQSIQNM RGNAHCVDCE TQNPKWASLN LGVLMCIECS
   481  GIHRSLGTRL SRVRSLELDD WPVELRKVMS SIGNDLANSI WEGSSQGQTK PSEKSTREEK
   541  ERWIRSKYEE KLFLAPLPCT ELSLGQQLLR ATADEDLQTA ILLLAHGSRE EVNETCGEGD
   601  GCTALHLACR KGNVVLAQLL IWYGVDVMAR DAHGNTALTY ARQASSQECI NVLLQYGCPD
   661  KCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
spleen: 18 nTPM
pituitary gland: 17 nTPM
testis: 16 nTPM
liver: 15 nTPM
prostate: 15 nTPM

Single-cell type

early spermatids: 65 nCPM
distal convoluted tubule cells: 52 nCPM
proximal tubule cells: 51 nCPM
renal connecting tubule cells: 43 nCPM
podocytes: 39 nCPM
renal collecting duct intercalated cells: 33 nCPM

Immune cell

basophil: 2 nTPM
neutrophil: 1 nTPM
eosinophil: 0.7 nTPM
naive B-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 10 nTPM
white matter: 10 nTPM
hypothalamus: 8.9 nTPM
basal ganglia: 8.7 nTPM
amygdala: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP4 as an antibody target. Whether an autoantibody or antibody against AGAP4 could matter depends on whether native AGAP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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