Seroatlas · Human Serome Atlas

AGAP11

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11

Also known as: AGA11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TF27
Gene
AGAP11
Canonical length
550 aa

OverviewNCBI Gene

No narrative summary is available for AGAP11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q8TF27|AGAP11
     1  MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL NNYSSSIPLT
    61  PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD PDKGRKALES HADTIGSGRA
   121  IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP
   181  GKWPSLATSA CAPISSSKSN GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP
   241  PSPHANKKKH LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ
   301  AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN PKWASLNLGV
   361  LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG NDLANSIWEG SSQGQTKPSI
   421  ESTREEKERW IRSKYEHKLF LAPLPCTELS LGQHLLRATA DEDLRTAILL LAHGSREEVN
   481  ETCGEGDGCT ALHLACRKGN VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL
   541  LQYGCPDECV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGAP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGAP11 as an antibody target. Whether an autoantibody or antibody against AGAP11 could matter depends on whether native AGAP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGAP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGAP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGAP11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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