Seroatlas · Human Serome Atlas

ADTRP

Androgen-dependent TFPI-regulating protein

Also known as: ADTRP_HUMAN, AIG1L, C6orf105, dJ413H6.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IZ2
Gene: ADTRP
Ensembl: ENSG00000111863
Chromosome: 6
Canonical length: 230 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables hydrolase activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; and negative regulation of secretion by cell. Located in caveola and cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q96IZ2|ADTRP
     1  MTKTSTCIYH FLVLSWYTFL NYYISQEGKD EVKPKILANG ARWKYMTLLN LLLQTIFYGV
    61  TCLDDVLKRT KGGKDIKFLT AFRDLLFTTL AFPVSTFVFL AFWILFLYNR DLIYPKVLDT
   121  VIPVWLNHAM HTFIFPITLA EVVLRPHSYP SKKTGLTLLA AASIAYISRI LWLYFETGTW
   181  VYPVFAKLSL LGLAAFFSLS YVFIASIYLL GEKLNHWKWG DMRQPRKKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADTRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 98 nTPM
small intestine: 93 nTPM
parathyroid gland: 87 nTPM
duodenum: 78 nTPM
colon: 76 nTPM
rectum: 55 nTPM

Single-cell type

late spermatids: 372 nCPM
retinal pigment epithelial cells: 311 nCPM
renal collecting duct intercalated cells: 209 nCPM
enterocytes: 199 nCPM
early spermatids: 196 nCPM
foveolar cells: 166 nCPM

Immune cell

naive CD4 T-cell: 15 nTPM
T-reg: 14 nTPM
memory CD4 T-cell: 3.7 nTPM
basophil: 2.8 nTPM
MAIT T-cell: 2.6 nTPM
total PBMC: 1.8 nTPM

Brain region

choroid plexus: 79 nTPM
cerebral cortex: 8.2 nTPM
basal ganglia: 7.6 nTPM
hippocampal formation: 6.9 nTPM
white matter: 6.1 nTPM
cerebellum: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADTRP as an antibody target. Whether an autoantibody or antibody against ADTRP could matter depends on whether native ADTRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADTRP is annotated at the cell surface, where native ADTRP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADTRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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