Seroatlas · Human Serome Atlas

ADPRS

ADP-ribosylhydrolase ARH3

Also known as: ADPRHL2, ADPRS_HUMAN, ARH3, FLJ20446

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NX46
Gene
ADPRS
Ensembl
ENSG00000116863
Chromosome
1
Canonical length
363 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q9NX46|ADPRS
     1  MAAAAMAAAA GGGAGAARSL SRFRGCLAGA LLGDCVGSFY EAHDTVDLTS VLRHVQSLEP
    61  DPGTPGSERT EALYYTDDTA MARALVQSLL AKEAFDEVDM AHRFAQEYKK DPDRGYGAGV
   121  VTVFKKLLNP KCRDVFEPAR AQFNGKGSYG NGGAMRVAGI SLAYSSVQDV QKFARLSAQL
   181  THASSLGYNG AILQALAVHL ALQGESSSEH FLKQLLGHME DLEGDAQSVL DARELGMEER
   241  PYSSRLKKIG ELLDQASVTR EEVVSELGNG IAAFESVPTA IYCFLRCMEP DPEIPSAFNS
   301  LQRTLIYSIS LGGDTDTIAT MAGAIAGAYY GMDQVPESWQ QSCEGYEETD ILAQSLHRVF
   361  QKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADPRS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 44 nTPM
  • adrenal gland: 35 nTPM
  • esophagus: 35 nTPM
  • skeletal muscle: 33 nTPM
  • skin: 33 nTPM
  • spinal cord: 31 nTPM

Single-cell type

  • esophageal apical cells: 132 nCPM
  • esophageal suprabasal cells: 120 nCPM
  • cytotrophoblasts: 100 nCPM
  • migrating cytotrophoblasts: 88 nCPM
  • syncytiotrophoblasts: 88 nCPM
  • esophageal basal cells: 82 nCPM

Immune cell

  • non-classical monocyte: 78 nTPM
  • intermediate monocyte: 74 nTPM
  • myeloid DC: 71 nTPM
  • eosinophil: 66 nTPM
  • classical monocyte: 58 nTPM
  • total PBMC: 58 nTPM

Brain region

  • white matter: 27 nTPM
  • choroid plexus: 26 nTPM
  • medulla oblongata: 24 nTPM
  • spinal cord: 23 nTPM
  • cerebellum: 21 nTPM
  • pons: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADPRS.

Disease | AllUniProt

Conditions ADPRS is implicated in, by any mechanism.

  • Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures (CONDSIAS) MIM:618170

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures
  • ADPRHL2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADPRS as an antibody target. Whether an autoantibody or antibody against ADPRS could matter depends on whether native ADPRS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADPRS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADPRS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADPRS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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