Seroatlas · Human Serome Atlas

ADPRH

ADP-ribosylhydrolase ARH1

Also known as: ADPRH_HUMAN, ARH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54922
Gene: ADPRH
Ensembl: ENSG00000144843
Chromosome: 3
Canonical length: 357 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>P54922|ADPRH
     1  MEKYVAAMVL SAAGDALGYY NGKWEFLQDG EKIHRQLAQL GGLDALDVGR WRVSDDTVMH
    61  LATAEALVEA GKAPKLTQLY YLLAKHYQDC MEDMDGRAPG GASVHNAMQL KPGKPNGWRI
   121  PFNSHEGGCG AAMRAMCIGL RFPHHSQLDT LIQVSIESGR MTHHHPTGYL GALASALFTA
   181  YAVNSRPPLQ WGKGLMELLP EAKKYIVQSG YFVEENLQHW SYFQTKWENY LKLRGILDGE
   241  SAPTFPESFG VKERDQFYTS LSYSGWGGSS GHDAPMIAYD AVLAAGDSWK ELAHRAFFHG
   301  GDSDSTAAIA GCWWGVMYGF KGVSPSNYEK LEYRNRLEET ARALYSLGSK EDTVISL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADPRH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.19
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

lung: 12 nTPM
tonsil: 12 nTPM
choroid plexus: 11 nTPM
skeletal muscle: 10 nTPM
spleen: 10 nTPM
placenta: 10 nTPM

Single-cell type

megakaryocytes: 37 nCPM
cdc: 22 nCPM
mast cells: 20 nCPM
syncytiotrophoblasts: 19 nCPM
thymic myoid cells: 19 nCPM
kupffer cells: 18 nCPM

Immune cell

eosinophil: 18 nTPM
classical monocyte: 18 nTPM
intermediate monocyte: 16 nTPM
basophil: 14 nTPM
non-classical monocyte: 13 nTPM
T-reg: 13 nTPM

Brain region

choroid plexus: 15 nTPM
white matter: 6.2 nTPM
thalamus: 6 nTPM
medulla oblongata: 5.8 nTPM
spinal cord: 5 nTPM
pons: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADPRH as an antibody target. Whether an autoantibody or antibody against ADPRH could matter depends on whether native ADPRH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADPRH is annotated as secreted, so native ADPRH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADPRH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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