Seroatlas · Human Serome Atlas

ADPGK

ADP-dependent glucokinase

Also known as: ADP-GK, ADPGK_HUMAN, DKFZp434B195

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRR6
Gene
ADPGK
Ensembl
ENSG00000159322
Chromosome
15
Canonical length
497 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Centrosome
Secretome location
Intracellular and membrane

OverviewNCBI Gene

ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

497 residues, UniProt reviewed canonical sequence.

>Q9BRR6|ADPGK
     1  MALWRGSAYA GFLALAVGCV FLLEPELPGS ALRSLWSSLC LGPAPAPPGP VSPEGRLAAA
    61  WDALIVRPVR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSILH SRNDLEEAFI
   121  HFMGKGAAAE RFFSDKETFH DIAQVASEFP GAQHYVGGNA ALIGQKFAAN SDLKVLLCGP
   181  VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWGQ LKAPHANRFI FSHDLSNGAM
   241  NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KELQRKRLLE VVTSISDIPT GIPVHLELAS
   301  MTNRELMSSI VHQQVFPAVT SLGLNEQELL FLTQSASGPH SSLSSWNGVP DVGMVSDILF
   361  WILKEHGRSK SRASDLTRIH FHTLVYHILA TVDGHWANQL AAVAAGARVA GTQACATETI
   421  DTSRVSLRAP QEFMTSHSEA GSRIVLNPNK PVVEWHREGI SFHFTPVLVC KDPIRTVGLG
   481  DAISAEGLFY SEVHPHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADPGK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • lung: 23 nTPM
  • tonsil: 23 nTPM
  • placenta: 22 nTPM
  • appendix: 20 nTPM
  • thymus: 20 nTPM

Single-cell type

  • neutrophils: 172 nCPM
  • kupffer cells: 166 nCPM
  • neutrophil progenitors: 164 nCPM
  • monocytes: 131 nCPM
  • microglia: 128 nCPM
  • monocyte progenitors: 123 nCPM

Immune cell

  • myeloid DC: 80 nTPM
  • classical monocyte: 76 nTPM
  • total PBMC: 65 nTPM
  • plasmacytoid DC: 63 nTPM
  • basophil: 59 nTPM
  • eosinophil: 57 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • hypothalamus: 12 nTPM
  • pons: 12 nTPM
  • white matter: 12 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.01
gnomAD missense Z
1.02
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribokinase-like
  • ADP-specific phosphofructokinase/glucokinase
  • ADP-specific Phosphofructokinase/Glucokinase conserved region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADPGK as an antibody target. Whether an autoantibody or antibody against ADPGK could matter depends on whether native ADPGK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADPGK is annotated as secreted, so native ADPGK circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADPGK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADPGK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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