Seroatlas · Human Serome Atlas

ADORA3

Adenosine receptor A3

Also known as: A3AR, AA3R_HUMAN, AD026

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMS8
Gene
ADORA3
Ensembl
ENSG00000282608
Chromosome
1
Canonical length
318 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>P0DMS8|ADORA3
     1  MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF IVSLALADIA
    61  VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR
   121  VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF
   181  SFLTWIFIPL VVMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA
   241  LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC
   301  VVCHPSDSLD TSIEKNSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADORA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 20 nTPM
  • adrenal gland: 14 nTPM
  • choroid plexus: 10 nTPM
  • midbrain: 9.9 nTPM
  • small intestine: 8.9 nTPM
  • cerebral cortex: 6.5 nTPM

Single-cell type

  • late spermatids: 4.7 nCPM
  • early spermatids: 2.9 nCPM
  • mast cells: 1.2 nCPM
  • epididymal efferent duct ciliated cells: 0.4 nCPM
  • microglia: 0.4 nCPM
  • macrophages: 0.3 nCPM

Immune cell

  • eosinophil: 603 nTPM
  • myeloid DC: 15 nTPM
  • basophil: 10 nTPM
  • classical monocyte: 8.1 nTPM
  • intermediate monocyte: 5.6 nTPM
  • plasmacytoid DC: 3 nTPM

Brain region

  • white matter: 36 nTPM
  • thalamus: 26 nTPM
  • medulla oblongata: 23 nTPM
  • spinal cord: 18 nTPM
  • pons: 16 nTPM
  • hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADORA3 as an antibody target. Whether an autoantibody or antibody against ADORA3 could matter depends on whether native ADORA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADORA3 is annotated at the cell surface, where native ADORA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADORA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADORA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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