Seroatlas · Human Serome Atlas

ADORA2B

Adenosine receptor A2b

Also known as: AA2BR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29275
Gene
ADORA2B
Ensembl
ENSG00000170425
Chromosome
17
Canonical length
332 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>P29275|ADORA2B
     1  MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA AADVAVGLFA
    61  IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAICVP LRYKSLVTGT
   121  RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNNCTEPWDG TTNESCCLVK CLFENVVPMS
   181  YMVYFNFFGC VLPPLLIMLV IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV
   241  GIFALCWLPV HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT
   301  FHKIISRYLL CQADVKSGNG QAGVQPALGV GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADORA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 16 nTPM
  • cerebral cortex: 13 nTPM
  • choroid plexus: 11 nTPM
  • esophagus: 10 nTPM
  • skin: 9.7 nTPM
  • colon: 9.6 nTPM

Single-cell type

  • basal keratinocytes: 82 nCPM
  • retinal pigment epithelial cells: 60 nCPM
  • suprabasal keratinocytes: 57 nCPM
  • esophageal basal cells: 47 nCPM
  • conjunctival goblet cells: 46 nCPM
  • bergmann glia: 42 nCPM

Immune cell

  • basophil: 17 nTPM
  • myeloid DC: 11 nTPM
  • intermediate monocyte: 5.9 nTPM
  • classical monocyte: 5 nTPM
  • eosinophil: 3.4 nTPM
  • non-classical monocyte: 3.2 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • basal ganglia: 9.5 nTPM
  • hippocampal formation: 8.7 nTPM
  • choroid plexus: 8.6 nTPM
  • thalamus: 6.9 nTPM
  • white matter: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADORA2B as an antibody target. Whether an autoantibody or antibody against ADORA2B could matter depends on whether native ADORA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADORA2B is annotated at the cell surface, where native ADORA2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADORA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADORA2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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