Seroatlas · Human Serome Atlas

ADNP2

Activity-dependent neuroprotector homeobox protein 2

Also known as: ADNP2_HUMAN, KIAA0863, ZNF508

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IQ32
Gene: ADNP2
Ensembl: ENSG00000101544
Chromosome: 18
Canonical length: 1131 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in nervous system development and regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1131 residues, UniProt reviewed canonical sequence.

>Q6IQ32|ADNP2
     1  MFQIPVENLD NIRKVRKKVK GILVDIGLDS CKELLKDLKG FDPGEKYFHN TSWGDVSLWE
    61  PSGKKVRYRT KPYCCGLCKY STKVLTSFKN HLHRYHEDEI DQELVIPCPN CVFASQPKVV
   121  GRHFRMFHAP VRKVQNYTVN ILGETKSSRS DVISFTCLKC NFSNTLYYSM KKHVLVAHFH
   181  YLINSYFGLR TEEMGEQPKT NDTVSIEKIP PPDKYYCKKC NANASSQDAL MYHILTSDIH
   241  RDLENKLRSV ISEHIKRTGL LKQTHIAPKP AAHLAAPANG SAPSAPAQPP CFHLALPQNS
   301  PSPAAGQPVT VAQGAPGSLT HSPPAAGQSH MTLVSSPLPV GQNSLTLQPP APQPVFLSHG
   361  VPLHQSVNPP VLPLSQPVGP VNKSVGTSVL PINQTVRPGV LPLTQPVGPI NRPVGPGVLP
   421  VSPSVTPGVL QAVSPGVLSV SRAVPSGVLP AGQMTPAGQM TPAGVIPGQT ATSGVLPTGQ
   481  MVQSGVLPVG QTAPSRVLPP GQTAPLRVIS AGQVVPSGLL SPNQTVSSSA VVPVNQGVNS
   541  GVLQLSQPVV SGVLPVGQPV RPGVLQLNQT VGTNILPVNQ PVRPGASQNT TFLTSGSILR
   601  QLIPTGKQVN GIPTYTLAPV SVTLPVPPGG LATVAPPQMP IQLLPSGAAA PMAGSMPGMP
   661  SPPVLVNAAQ SVFVQASSSA ADTNQVLKQA KQWKTCPVCN ELFPSNVYQV HMEVAHKHSE
   721  SKSGEKLEPE KLAACAPFLK WMREKTVRCL SCKCLVSEEE LIHHLLMHGL GCLFCPCTFH
   781  DIKGLSEHSR NRHLGKKKLP MDYSNRGFQL DVDANGNLLF PHLDFITILP KEKLGEREVY
   841  LAILAGIHSK SLVPVYVKVR PQAEGTPGST GKRVSTCPFC FGPFVTTEAY ELHLKERHHI
   901  MPTVHTVLKS PAFKCIHCCG VYTGNMTLAA IAVHLVRCRS APKDSSSDLQ AQPGFIHNSE
   961  LLLVSGEVMH DSSFSVKRKL PDGHLGAEDQ RHGEEQPPIL NADAAPGPEK VTSVVPFKRQ
  1021  RNESRTEGPI VKDEALQILA LDPKKYEGRS YEEKKQFLKD YFHKKPYPSK KEIELLSSLF
  1081  WVWKIDVASF FGKRRYICMK AIKNHKPSVL LGFDMSELKN VKHRLNFEYE P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADNP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 39 nTPM
testis: 21 nTPM
skin: 13 nTPM
retina: 11 nTPM
epididymis: 10 nTPM
parathyroid gland: 9.1 nTPM

Single-cell type

neutrophils: 127 nCPM
rod photoreceptor cells: 94 nCPM
endometrial glandular cells: 86 nCPM
urothelial cells: 86 nCPM
cone photoreceptor cells: 85 nCPM
ocular epithelial cells: 78 nCPM

Immune cell

memory CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.4 nTPM
gdT-cell: 1.2 nTPM
non-classical monocyte: 1.2 nTPM
memory CD8 T-cell: 1 nTPM
memory B-cell: 0.9 nTPM

Brain region

cerebral cortex: 108 nTPM
thalamus: 80 nTPM
basal ganglia: 77 nTPM
pons: 75 nTPM
white matter: 75 nTPM
medulla oblongata: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.7
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADNP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADNP2 as an antibody target. Whether an autoantibody or antibody against ADNP2 could matter depends on whether native ADNP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADNP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADNP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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