ADM5
Putative adrenomedullin-5-like protein
Also known as: ADM5_HUMAN, AM5, C19orf76
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- C9JUS6
- Gene
- ADM5
- Ensembl
- ENSG00000224420
- Chromosome
- 19
- Canonical length
- 153 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of heart rate; and regulation of urine volume. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>C9JUS6|ADM5
1 MTIHILILLL LLAFSAQGDL DTAARRGQHQ VPQHRGHVCY LGVCRTHRLA EIIYWIRCLH
61 QGALGEGQPR APGPLQLWAP PVARGGSPAR FPGFRPAARG LAQCPARWVT SGTARPLLGF
121 SLPICMLELL LHISSPLTPA PETVFPSPSP GCDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ADM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 17 nTPM
- breast: 13 nTPM
- spleen: 11 nTPM
- fallopian tube: 11 nTPM
- skin: 8.4 nTPM
- endometrium: 7.8 nTPM
Single-cell type
- vascular endothelial cells: 39 nCPM
- esophageal apical cells: 17 nCPM
- early spermatids: 11 nCPM
- endometrial secretory cells: 11 nCPM
- breast secretory cells: 8.4 nCPM
- late spermatids: 7.3 nCPM
Immune cell
- memory CD8 T-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 12 nTPM
- hypothalamus: 6.2 nTPM
- cerebral cortex: 5.5 nTPM
- pons: 5.1 nTPM
- thalamus: 4.9 nTPM
- white matter: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.4
- gnomAD missense Z
- 0.9
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- positive regulation of heart rate
- regulation of systemic arterial blood pressure
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ADM5 as an antibody target. Whether an autoantibody or antibody against ADM5 could matter depends on whether native ADM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ADM5 is annotated as secreted, so native ADM5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ADM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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