ADM2
Protein ADM2
Also known as: ADM2_HUMAN, AM2, FLJ21135
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7Z4H4
- Gene
- ADM2
- Ensembl
- ENSG00000128165
- Chromosome
- 22
- Canonical length
- 148 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
Canonical amino-acid sequenceUniProt
148 residues, UniProt reviewed canonical sequence.
>Q7Z4H4|ADM2
1 MARIPTAALG CISLLCLQLP GSLSRSLGGD PRPVKPREPP ARSPSSSLQP RHPAPRPVVW
61 KLHRALQAQR GAGLAPVMGQ PLRDGGRQHS GPRRHSGPRR TQAQLLRVGC VLGTCQVQNL
121 SHRLWQLMGP AGRQDSAPVD PSSPHSYGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ADM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 15 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 15 nTPM
- thyroid gland: 11 nTPM
- kidney: 7.7 nTPM
- salivary gland: 5.3 nTPM
- stomach: 3.8 nTPM
- duodenum: 3.5 nTPM
Single-cell type
- epididymal efferent duct absorptive cells: 20 nCPM
- gastric chief cells: 12 nCPM
- pancreatic acinar cells: 9.6 nCPM
- epididymal principal cells: 9.3 nCPM
- proximal tubule cells: 8.6 nCPM
- plasma cells: 8.2 nCPM
Immune cell
- neutrophil: 0.2 nTPM
- naive B-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebellum: 1.9 nTPM
- thalamus: 1.5 nTPM
- cerebral cortex: 1.4 nTPM
- midbrain: 1.1 nTPM
- pons: 1.1 nTPM
- basal ganglia: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.11
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- adrenomedullin receptor signaling pathway
- angiogenesis
- feeding behavior
- negative regulation of blood pressure
- positive regulation of angiogenesis
- positive regulation of gene expression
- positive regulation of heart rate
- protein phosphorylation
- regulation of systemic arterial blood pressure
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ADM2 as an antibody target. Whether an autoantibody or antibody against ADM2 could matter depends on whether native ADM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ADM2 is annotated as secreted, so native ADM2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ADM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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