Seroatlas · Human Serome Atlas

ADM

Pro-adrenomedullin

Also known as: ADML_HUMAN, AM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P35318
Gene: ADM
Ensembl: ENSG00000148926
Chromosome: 11
Canonical length: 185 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>P35318|ADM
     1  MKLVSVALMY LGSLAFLGAD TARLDVASEF RKKWNKWALS RGKRELRMSS SYPTGLADVK
    61  AGPAQTLIRP QDMKGASRSP EDSSPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL
   121  AHQIYQFTDK DKDNVAPRSK ISPQGYGRRR RRSLPEAGPG RTLVSSKPQA HGAPAPPSGS
   181  APHFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 340 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 340 nTPM
cervix: 229 nTPM
vagina: 218 nTPM
breast: 195 nTPM
skin: 168 nTPM
lung: 158 nTPM

Single-cell type

extravillous trophoblasts: 1,814 nCPM
syncytiotrophoblasts: 1,453 nCPM
esophageal apical cells: 1,277 nCPM
neutrophils: 524 nCPM
migrating cytotrophoblasts: 407 nCPM
esophageal suprabasal cells: 299 nCPM

Immune cell

neutrophil: 243 nTPM
non-classical monocyte: 14 nTPM
intermediate monocyte: 7.7 nTPM
classical monocyte: 7 nTPM
myeloid DC: 2.4 nTPM
total PBMC: 1.9 nTPM

Brain region

cerebellum: 51 nTPM
thalamus: 36 nTPM
medulla oblongata: 33 nTPM
midbrain: 31 nTPM
basal ganglia: 30 nTPM
white matter: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0.04
gnomAD missense Z: -0.11
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity
signaling receptor binding
adrenomedullin receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADM as an antibody target. Whether an autoantibody or antibody against ADM could matter depends on whether native ADM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADM is annotated as secreted, so native ADM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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