ADK

Protein identityUniProt · HPA

UniProt accession

P55263

Gene

ADK

Ensembl

ENSG00000156110

Chromosome

10

Canonical length

362 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>P55263|ADK
     1  MAAAEEEPKP KKLKVEAPQA LRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED
    61  KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA
   121  AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR
   181  VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN
   241  ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA
   301  VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD
   361  FH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

141 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADK.

Disease | AllUniProt

Conditions ADK is implicated in, by any mechanism.

• Hypermethioninemia due to adenosine kinase deficiency (HMAKD) MIM:614300

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 184 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Adenosine kinase deficiency
• ADK-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.8

gnomAD pLI

0

gnomAD missense Z

1.5

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• AMP salvage
• dAMP salvage
• GMP salvage
• purine nucleobase metabolic process
• purine ribonucleoside salvage
• ribonucleoside monophosphate biosynthetic process
• dATP biosynthetic process

Molecular functions

• ATP binding
• deoxyadenosine kinase activity
• metal ion binding
• RNA binding
• adenosine kinase activity

Cellular components

• cytosol
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Carbohydrate/purine kinase, PfkB, conserved site
• Carbohydrate kinase PfkB
• Ribokinase-like
• pfkB family carbohydrate kinase
• Adenosine kinase

KeywordsUniProt

• Acetylation
• ATP-binding
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Purine salvage
• Transferase