Seroatlas · Human Serome Atlas

ADISSP

Adipose-secreted signaling protein

Also known as: ADSSP_HUMAN, C20orf27, FLJ20550

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZN8
Gene: ADISSP
Ensembl: ENSG00000101220
Chromosome: 20
Canonical length: 174 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Enables protein phosphatase 1 binding activity. Involved in positive regulation of non-canonical NF-kappaB signal transduction and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>Q9GZN8|ADISSP
     1  MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS FLVKVGFLKI
    61  LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE GYSVKCEYSA HKEGVLKEEI
   121  LLACEGGTGT CVRVTVQARV MDRHHGTPML LDGVKCVGAE LEYDSEHSDW HGFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADISSP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 319 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 319 nTPM
colon: 131 nTPM
bone marrow: 98 nTPM
stomach: 95 nTPM
urinary bladder: 86 nTPM
ovary: 74 nTPM

Single-cell type

decidual stromal cells: 786 nCPM
hofbauer cells: 205 nCPM
monocyte progenitors: 151 nCPM
smooth muscle cells: 145 nCPM
ovarian stromal cells: 129 nCPM
endometrial stromal cells: 125 nCPM

Immune cell

intermediate monocyte: 249 nTPM
non-classical monocyte: 236 nTPM
myeloid DC: 200 nTPM
classical monocyte: 145 nTPM
total PBMC: 87 nTPM
MAIT T-cell: 42 nTPM

Brain region

basal ganglia: 213 nTPM
pons: 94 nTPM
hypothalamus: 84 nTPM
midbrain: 77 nTPM
thalamus: 75 nTPM
medulla oblongata: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0.01
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein phosphatase 1 binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Adipose-secreted signaling protein
Domain of unknown function (DUF4517)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADISSP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADISSP as an antibody target. Whether an autoantibody or antibody against ADISSP could matter depends on whether native ADISSP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADISSP is annotated as secreted, so native ADISSP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADISSP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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