Seroatlas · Human Serome Atlas

ADIRF

Adipogenesis regulatory factor

Also known as: ADIRF_HUMAN, AFRO, APM2, C10orf116

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15847
Gene
ADIRF
Ensembl
ENSG00000148671
Chromosome
10
Canonical length
76 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>Q15847|ADIRF
     1  MASKGLQDLK QQVEGTAQEA VSAAGAAAQQ VVDQATEAGQ KAMDQLAKTT QETIDKTANQ
    61  ASDTFSGIGK KFGLLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADIRF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
2,351 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 2,351 nTPM
  • adipose tissue: 1,338 nTPM
  • breast: 1,016 nTPM
  • prostate: 467 nTPM
  • small intestine: 463 nTPM
  • duodenum: 447 nTPM

Single-cell type

  • enterocytes: 10,460 nCPM
  • esophageal apical cells: 7,377 nCPM
  • vascular smooth muscle cells: 5,029 nCPM
  • ocular epithelial cells: 4,551 nCPM
  • urothelial cells: 3,177 nCPM
  • epididymal efferent duct absorptive cells: 2,189 nCPM

Immune cell

  • naive CD4 T-cell: 2.6 nTPM
  • naive CD8 T-cell: 1.9 nTPM
  • memory CD4 T-cell: 1 nTPM
  • MAIT T-cell: 0.6 nTPM
  • T-reg: 0.5 nTPM
  • myeloid DC: 0.3 nTPM

Brain region

  • hypothalamus: 169 nTPM
  • medulla oblongata: 127 nTPM
  • amygdala: 113 nTPM
  • hippocampal formation: 108 nTPM
  • white matter: 103 nTPM
  • cerebral cortex: 101 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.04
gnomAD missense Z
-0.05
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Adipogenesis regulatory factor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADIRF as an antibody target. Whether an autoantibody or antibody against ADIRF could matter depends on whether native ADIRF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADIRF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADIRF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADIRF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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