Seroatlas · Human Serome Atlas

ADIG

Adipogenin

Also known as: ADIG_HUMAN, MGC39724, RP5-1100H13.2, SMAF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0VDE8
Gene
ADIG
Ensembl
ENSG00000182035
Chromosome
20
Canonical length
80 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

ADIG/SMAF1 is an adipocyte-specific protein that plays a role in adipocyte differentiation (Kim et al., 2005 [PubMed 15567149]; Hong et al., 2005 [PubMed 16132694]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

80 residues, UniProt reviewed canonical sequence.

>Q0VDE8|ADIG
     1  MKYPLMPLVN DLTFSFLVFW FCLPVGLLLL LIIWLRFLLS QDSEENDSSV CLDWEPWSKG
    61  PAEFCWKGTL HGQEKERPCW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADIG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • epididymis: 2.4 nTPM
  • thyroid gland: 1 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM

Single-cell type

  • late spermatids: 1,120 nCPM
  • early spermatids: 245 nCPM
  • late primary spermatocytes: 14 nCPM
  • ependymal cells: 1.8 nCPM
  • epididymal efferent duct ciliated cells: 1.7 nCPM
  • undifferentiated spermatogonia: 1.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 1.3 nTPM
  • cerebral cortex: 1 nTPM
  • hippocampal formation: 0.9 nTPM
  • hypothalamus: 0.9 nTPM
  • thalamus: 0.8 nTPM
  • amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Adipogenin
  • Adipogenin

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADIG as an antibody target. Whether an autoantibody or antibody against ADIG could matter depends on whether native ADIG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADIG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADIG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADIG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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