Seroatlas · Human Serome Atlas

ADI1

Acireductone dioxygenase

Also known as: APL1, ARD, FLJ10913, HMFT1638, MTCBP-1, mtnD, MTND_HUMAN, SIPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV57
Gene
ADI1
Ensembl
ENSG00000182551
Chromosome
2
Canonical length
179 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q9BV57|ADI1
     1  MVQAWYMDDA PGDPRQPHRP DPGRPVGLEQ LRRLGVLYWK LDADKYENDP ELEKIRRERN
    61  YSWMDIITIC KDKLPNYEEK IKMFYEEHLH LDDEIRYILD GSGYFDVRDK EDQWIRIFME
   121  KGDMVTLPAG IYHRFTVDEK NYTKAMRLFV GEPVWTAYNR PADHFEARGQ YVKFLAQTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
552 nTPM

Expression across tissuesHPA

Tissue

  • liver: 552 nTPM
  • kidney: 187 nTPM
  • heart muscle: 137 nTPM
  • blood vessel: 134 nTPM
  • skeletal muscle: 119 nTPM
  • duodenum: 98 nTPM

Single-cell type

  • hepatocytes: 309 nCPM
  • megakaryocytes: 74 nCPM
  • platelets: 56 nCPM
  • thymic myoid cells: 49 nCPM
  • salivary ionocytes: 46 nCPM
  • hepatic stellate cells: 45 nCPM

Immune cell

  • eosinophil: 338 nTPM
  • total PBMC: 189 nTPM
  • plasmacytoid DC: 187 nTPM
  • classical monocyte: 135 nTPM
  • myeloid DC: 128 nTPM
  • intermediate monocyte: 127 nTPM

Brain region

  • choroid plexus: 65 nTPM
  • white matter: 45 nTPM
  • medulla oblongata: 44 nTPM
  • cerebral cortex: 43 nTPM
  • pons: 42 nTPM
  • basal ganglia: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADI1 as an antibody target. Whether an autoantibody or antibody against ADI1 could matter depends on whether native ADI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADI1 is annotated at the cell surface, where native ADI1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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