Seroatlas · Human Serome Atlas

ADCYAP1

Pituitary adenylate cyclase-activating polypeptide

Also known as: PACA_HUMAN, PACAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P18509
Gene: ADCYAP1
Ensembl: ENSG00000141433
Chromosome: 18
Canonical length: 176 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>P18509|ADCYAP1
     1  MTMCSGARLA LLVYGIIMHS SVYSSPAAAG LRFPGIRPEE EAYGEDGNPL PDFDGSEPPG
    61  AGSPASAPRA AAAWYRPAGR RDVAHGILNE AYRKVLDQLS AGKHLQSLVA RGVGGSLGGG
   121  AGDDAEPLSK RHSDGIFTDS YSRYRKQMAV KKYLAAVLGK RYKQRVKNKG RRIAYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCYAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 12 nTPM
appendix: 10 nTPM
cerebral cortex: 7.4 nTPM
gallbladder: 6.6 nTPM
pancreas: 4.5 nTPM
pituitary gland: 3 nTPM

Single-cell type

mast cells: 647 nCPM
pancreatic islet cells: 94 nCPM
brain excitatory neurons: 23 nCPM
pancreatic acinar cells: 21 nCPM
other brain neurons: 21 nCPM
retinal ganglion cells: 16 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 72 nTPM
hypothalamus: 54 nTPM
thalamus: 42 nTPM
pons: 32 nTPM
spinal cord: 15 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.52
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

neuropeptide hormone activity
peptide hormone receptor binding
signaling receptor binding
type 1 vasoactive intestinal polypeptide receptor binding
type 2 vasoactive intestinal polypeptide receptor binding
pituitary adenylate cyclase activating polypeptide activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCYAP1 as an antibody target. Whether an autoantibody or antibody against ADCYAP1 could matter depends on whether native ADCYAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCYAP1 is annotated as secreted, so native ADCYAP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADCYAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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