Seroatlas · Human Serome Atlas

ADCY4

Adenylate cyclase type 4

Also known as: AC4, ADCY4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFM4
Gene
ADCY4
Ensembl
ENSG00000129467
Chromosome
14
Canonical length
1077 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

1077 residues, UniProt reviewed canonical sequence.

>Q8NFM4|ADCY4
     1  MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA SGRELTSDPS
    61  FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL LALGHAFLFT GGVVSAWDQV
   121  SYFLFVIFTA YAMLPLGMRD AAVAGLASSL SHLLVLGLYL GPQPDSRPAL LPQLAANAVL
   181  FLCGNVAGVY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK
   241  AEIMARLQAG QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE
   301  LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRAATG
   361  VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG
   421  AYAVEDAGME HRDPYLRELG EPTYLVIDPR AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR
   481  YLESWGAAKP FAHLSHGDSP VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK
   541  FFQVIEQLNS QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI
   601  IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP ALSGLVATRP
   661  GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS MISNLSWELP GSLPLISVPY
   721  SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW LAASCSLFLH SHAWLSECLI VRLYLGPLDS
   781  RPGVLKEPKL MGAISFFIFF FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL
   841  LLENVLPAHV APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR
   901  LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE RSCSHLGTMV
   961  EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ KPQYDIWGNT VNVASRMEST
  1021  GVLGKIQVTE ETAWALQSLG YTCYSRGVIK VKGKGQLCTY FLNTDLTRTG PPSATLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCY4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 22 nTPM
  • heart muscle: 20 nTPM
  • breast: 19 nTPM
  • kidney: 13 nTPM
  • endometrium: 12 nTPM
  • lung: 12 nTPM

Single-cell type

  • vascular endothelial cells: 39 nCPM
  • lymphatic endothelial cells: 27 nCPM
  • epicardial cells: 9.1 nCPM
  • late spermatids: 8 nCPM
  • foveolar cells: 5.3 nCPM
  • pericytes: 4.2 nCPM

Immune cell

  • basophil: 2.9 nTPM
  • myeloid DC: 0.3 nTPM
  • eosinophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • thalamus: 3.3 nTPM
  • amygdala: 2.8 nTPM
  • medulla oblongata: 2.7 nTPM
  • pons: 2.4 nTPM
  • midbrain: 2.1 nTPM
  • spinal cord: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.43
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCY4 as an antibody target. Whether an autoantibody or antibody against ADCY4 could matter depends on whether native ADCY4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCY4 is annotated at the cell surface, where native ADCY4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADCY4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADCY4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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