ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3
Also known as: ADAT3_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q96EY9
- Gene
- ADAT3
- Canonical length
- 351 aa
- Protein class
- Human disease related genes, Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for ADAT3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
351 residues, UniProt reviewed canonical sequence.
>Q96EY9|ADAT3
1 MEPAPGLVEQ PKCLEAGSPE PEPAPWQALP VLSEKQSGDV ELVLAYAAPV LDKRQTSRLL
61 KEVSALHPLP AQPHLKRVRP SRDAGSPHAL EMLLCLAGPA SGPRSLAELL PRPAVDPRGL
121 GQPFLVPVPA RPPLTRGQFE EARAHWPTSF HEDKQVTSAL AGRLFSTQER AAMQSHMERA
181 VWAARRAAAR GLRAVGAVVV DPASDRVLAT GHDCSCADNP LLHAVMVCVD LVARGQGRGT
241 YDFRPFPACS FAPAAAPQAV RAGAVRKLDA DEDGLPYLCT GYDLYVTREP CAMCAMALVH
301 ARILRVFYGA PSPDGALGTR FRIHARPDLN HRFQVFRGVL EEQCRWLDPD TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ADAT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- skin: 13 nTPM
- esophagus: 10 nTPM
- spinal cord: 9.7 nTPM
- salivary gland: 7.9 nTPM
- colon: 7.3 nTPM
- kidney: 7.1 nTPM
Single-cell type
- basal prostatic cells: 0.3 nCPM
- endometrial secretory cells: 0.3 nCPM
- fallopian tube ciliated cells: 0.3 nCPM
- colonocytes: 0.2 nCPM
- endometrial ciliated cells: 0.2 nCPM
- neutrophil progenitors: 0.2 nCPM
Immune cell
- plasmacytoid DC: 13 nTPM
- NK-cell: 4.2 nTPM
- naive B-cell: 2.6 nTPM
- T-reg: 2.6 nTPM
- memory CD8 T-cell: 2.3 nTPM
- naive CD8 T-cell: 2.3 nTPM
Brain region
- medulla oblongata: 18 nTPM
- white matter: 18 nTPM
- pons: 15 nTPM
- thalamus: 13 nTPM
- spinal cord: 13 nTPM
- cerebral cortex: 13 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ADAT3.
Disease | AllUniProt
Conditions ADAT3 is implicated in, by any mechanism.
- Neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies (NEDBGF) MIM:615286
Disease | GeneticClinVar
4 pathogenic / likely-pathogenic of 174 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Intellectual disability-strabismus syndrome
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- -0.27
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ADAT3 as an antibody target. Whether an autoantibody or antibody against ADAT3 could matter depends on whether native ADAT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ADAT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ADAT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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