ADARB2

Protein identityUniProt · HPA

UniProt accession

Q9NS39

Gene

ADARB2

Ensembl

ENSG00000185736

Chromosome

10

Canonical length

739 aa

Protein class

Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

739 residues, UniProt reviewed canonical sequence.

>Q9NS39|ADARB2
     1  MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKHLS PGITNTEDDD
    61  TLSTSSAEVK ENRNVGNLAA RPPPSGDRAR GGAPGAKRKR PLEEGNGGHL CKLQLVWKKL
   121  SWSVAPKNAL VQLHELRPGL QYRTVSQTGP VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR
   181  AAELALRSFV QFPNACQAHL AMGGGPGPGT DFTSDQADFP DTLFQEFEPP APRPGLAGGR
   241  PGDAALLSAA YGRRRLLCRA LDLVGPTPAT PAAPGERNPV VLLNRLRAGL RYVCLAEPAE
   301  RRARSFVMAV SVDGRTFEGS GRSKKLARGQ AAQAALQELF DIQMPGHAPG RARRTPMPQE
   361  FADSISQLVT QKFREVTTDL TPMHARHKAL AGIVMTKGLD ARQAQVVALS SGTKCISGEH
   421  LSDQGLVVND CHAEVVARRA FLHFLYTQLE LHLSKRREDS ERSIFVRLKE GGYRLRENIL
   481  FHLYVSTSPC GDARLHSPYE ITTDLHSSKH LVRKFRGHLR TKIESGEGTV PVRGPSAVQT
   541  WDGVLLGEQL ITMSCTDKIA RWNVLGLQGA LLSHFVEPVY LQSIVVGSLH HTGHLARVMS
   601  HRMEGVGQLP ASYRHNRPLL SGVSDAEARQ PGKSPPFSMN WVVGSADLEI INATTGRRSC
   661  GGPSRLCKHV LSARWARLYG RLSTRTPSPG DTPSMYCEAK LGAHTYQSVK QQLFKAFQKA
   721  GLGTWVRKPP EQQQFLLTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADARB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

33 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.38

gnomAD pLI

0.86

gnomAD missense Z

1.73

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 3'-UTR-mediated mRNA stabilization
• adenosine to inosine editing
• mRNA processing
• negative regulation of mRNA modification
• RNA processing

Molecular functions

• double-stranded RNA adenosine deaminase activity
• double-stranded RNA binding
• metal ion binding
• mRNA binding
• RNA binding
• RNA sequestering activity
• tRNA-specific adenosine deaminase activity

Cellular components

• cytoplasm
• nucleolus
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Adenosine deaminase/editase
• Double-stranded RNA-binding domain
• Double-stranded RNA binding motif
• Adenosine-deaminase (editase) domain
• ADAR3, first double-stranded RNA binding domain

KeywordsUniProt

• Metal-binding
• mRNA processing
• Nucleus
• Repeat
• RNA-binding
• Zinc

InteractionsUniProt · HPA

Protein binding partners of ADARB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KPNA2