Seroatlas · Human Serome Atlas

ADAP2

Arf-GAP with dual PH domain-containing protein 2

Also known as: ADAP2_HUMAN, CENTA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPF8
Gene: ADAP2
Ensembl: ENSG00000184060
Chromosome: 17
Canonical length: 381 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q9NPF8|ADAP2
     1  MGDRERNKKR LLELLRAPDT GNAHCADCGA ADPDWASYKL GIFICLNCCG VHRNFPDISR
    61  VKSVRLDFWD DSIVEFMIHN GNLRVKAKFE ARVPAFYYIP QANDCLVLKE QWIRAKYERR
   121  EFMADGETIS LPGNREGFLW KRGRDNSQFL RRKFVLLARE GLLKYFTKEQ GKSPKAVISI
   181  KDLNATFQTE KIGHPHGLQI TYRRDGHTRN LFVYHESGKE IVDWFNALRA ARLQYLKMAF
   241  PELPESELVP FLTRNYLKQG FMEKTGPKQK EPFKKRWFAL DCHERRLLYY KNPLDAFEQG
   301  QVFLGNKEQG YEAYEDLPKG IRGNRWKAGL TIVTPERRFV LTCPSEKEQQ EWLESLRGVL
   361  SSPLTPLNRL TASTESGRSS R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

spleen: 21 nTPM
placenta: 19 nTPM
appendix: 14 nTPM
adipose tissue: 11 nTPM
liver: 10 nTPM
lung: 9.2 nTPM

Single-cell type

kupffer cells: 470 nCPM
hofbauer cells: 334 nCPM
macrophages: 245 nCPM
microglia: 227 nCPM
extravillous trophoblasts: 144 nCPM
monocytes: 108 nCPM

Immune cell

non-classical monocyte: 44 nTPM
intermediate monocyte: 34 nTPM
classical monocyte: 23 nTPM
myeloid DC: 13 nTPM
total PBMC: 6.7 nTPM
memory B-cell: 3 nTPM

Brain region

thalamus: 28 nTPM
white matter: 24 nTPM
medulla oblongata: 23 nTPM
pons: 20 nTPM
choroid plexus: 17 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heart development

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAP2 as an antibody target. Whether an autoantibody or antibody against ADAP2 could matter depends on whether native ADAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAP2 is annotated at the cell surface, where native ADAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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