ADAMTSL4-AS1
Uncharacterized protein ADAMTSL4-AS1
Also known as: A4AS1_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- Q5T5F5
- Gene
- ADAMTSL4-AS1
- Canonical length
- 129 aa
OverviewNCBI Gene
No narrative summary is available for ADAMTSL4-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
129 residues, UniProt reviewed canonical sequence.
>Q5T5F5|ADAMTSL4-AS1
1 MWLWQDIQCC PAPPSAPPRA LEPGRAPPPP GEGLGAGIPS LSPPQKKPQS VGICVRQKGR
61 QKAGLEKGNR KKELRQANCP SLRPQRKGAD TRRLPRETRP TKKRTAAAQP FLQLWNPAPH
121 TSNGRTGDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ADAMTSL4-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.77
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ADAMTSL4-AS1 as an antibody target. Whether an autoantibody or antibody against ADAMTSL4-AS1 could matter depends on whether native ADAMTSL4-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ADAMTSL4-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ADAMTSL4-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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