Seroatlas · Human Serome Atlas

ADAD2

Adenosine deaminase domain-containing protein 2

Also known as: ADAD2_HUMAN, FLJ00337, TENRL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCV1
Gene
ADAD2
Ensembl
ENSG00000140955
Chromosome
16
Canonical length
583 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing; adenosine to inosine editing; and spermatid development. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q8NCV1|ADAD2
     1  MASASQGADD DGSRRKPRLA ASLQISPQPR PWRPLPAQAQ SAWGPAPAPA TYRAEGGWPQ
    61  VSVLRDSGPG AGAGVGELGA ARAWENLGEQ MGKAPRVPVP PAGLSLPLKD PPASQAVSLL
   121  TEYAASLGIF LLFREDQPPG PCFPFSVSAE LDGVVCPAGT ANSKTEAKQQ AALSALCYIR
   181  SQLENPESPQ TSSRPPLAPL SVENILTHEQ RCAALVSAGF DLLLDERSPY WACKGTVAGV
   241  ILEREIPRAR GHVKEIYKLV ALGTGSSCCA GWLEFSGQQL HDCHGLVIAR RALLRFLFRQ
   301  LLLATQGGPK GKEQSVLAPQ PGPGPPFTLK PRVFLHLYIS NTPKGAARDI YLPPTSEGGL
   361  PHSPPMRLQA HVLGQLKPVC YVAPSLCDTH VGCLSASDKL ARWAVLGLGG ALLAHLVSPL
   421  YSTSLILADS CHDPPTLSRA IHTRPCLDSV LGPCLPPPYV RTALHLFAGP PVAPSEPTPD
   481  TCRGLSLNWS LGDPGIEVVD VATGRVKANA ALGPPSRLCK ASFLRAFHQA ARAVGKPYLL
   541  ALKTYEAAKA GPYQEARRQL SLLLDQQGLG AWPSKPLVGK FRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • testis: 61 nTPM
  • spleen: 3.5 nTPM
  • basal ganglia: 2 nTPM
  • cerebral cortex: 1.9 nTPM
  • amygdala: 1.6 nTPM
  • hippocampal formation: 1 nTPM

Single-cell type

  • retinal pigment epithelial cells: 269 nCPM
  • late primary spermatocytes: 172 nCPM
  • early spermatids: 71 nCPM
  • early primary spermatocytes: 65 nCPM
  • oocytes: 55 nCPM
  • undifferentiated spermatogonia: 30 nCPM

Immune cell

  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 5.3 nTPM
  • cerebral cortex: 3.3 nTPM
  • basal ganglia: 1.2 nTPM
  • white matter: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • hypothalamus: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAD2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 186 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
-2.36
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAD2 as an antibody target. Whether an autoantibody or antibody against ADAD2 could matter depends on whether native ADAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADAD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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