ACYP2
Acylphosphatase-2
Also known as: ACYP2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P14621
- Gene
- ACYP2
- Ensembl
- ENSG00000170634
- Chromosome
- 2
- Canonical length
- 99 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>P14621|ACYP2
1 MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN
61 SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ACYP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 191 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 191 nTPM
- tongue: 149 nTPM
- spinal cord: 104 nTPM
- midbrain: 95 nTPM
- basal ganglia: 84 nTPM
- cerebral cortex: 78 nTPM
Single-cell type
- myonuclei: 1,236 nCPM
- choroid plexus epithelial cells: 550 nCPM
- oligodendrocytes: 477 nCPM
- sertoli cells: 471 nCPM
- cardiomyocytes: 442 nCPM
- thyrotrophs: 437 nCPM
Immune cell
- basophil: 41 nTPM
- plasmacytoid DC: 33 nTPM
- memory B-cell: 29 nTPM
- naive B-cell: 27 nTPM
- eosinophil: 26 nTPM
- myeloid DC: 20 nTPM
Brain region
- white matter: 76 nTPM
- cerebellum: 75 nTPM
- hypothalamus: 71 nTPM
- basal ganglia: 69 nTPM
- spinal cord: 67 nTPM
- thalamus: 65 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.51
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ACYP2 as an antibody target. Whether an autoantibody or antibody against ACYP2 could matter depends on whether native ACYP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ACYP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ACYP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...