Seroatlas · Human Serome Atlas

ACYP1

Acylphosphatase-1

Also known as: ACYP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P07311
Gene: ACYP1
Ensembl: ENSG00000119640
Chromosome: 14
Canonical length: 99 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>P07311|ACYP1
     1  MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG QLQGPISKVR
    61  HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACYP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 50 nTPM
choroid plexus: 44 nTPM
cerebral cortex: 43 nTPM
retina: 41 nTPM
cerebellum: 38 nTPM
pituitary gland: 37 nTPM

Single-cell type

fallopian tube ciliated cells: 147 nCPM
cardiomyocytes: 141 nCPM
epididymal efferent duct ciliated cells: 138 nCPM
late primary spermatocytes: 135 nCPM
respiratory ciliated cells: 126 nCPM
endometrial ciliated cells: 93 nCPM

Immune cell

T-reg: 25 nTPM
memory CD4 T-cell: 18 nTPM
eosinophil: 18 nTPM
naive CD4 T-cell: 16 nTPM
naive CD8 T-cell: 15 nTPM
naive B-cell: 14 nTPM

Brain region

white matter: 50 nTPM
hypothalamus: 47 nTPM
pons: 43 nTPM
choroid plexus: 41 nTPM
thalamus: 40 nTPM
medulla oblongata: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.07
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

phosphate-containing compound metabolic process

Molecular functions

acylphosphatase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACYP1 as an antibody target. Whether an autoantibody or antibody against ACYP1 could matter depends on whether native ACYP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACYP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACYP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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