Seroatlas · Human Serome Atlas

ACY3

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Also known as: ACY-3, ACY3_HUMAN, HCBP1, MGC9740

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HD9
Gene: ACY3
Ensembl: ENSG00000132744
Chromosome: 11
Canonical length: 319 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to enable aminoacylase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>Q96HD9|ACY3
     1  MCSLPVPREP LRRVAVTGGT HGNEMSGVYL ARHWLHAPAE LQRASFSAVP VLANPAATSG
    61  CRRYVDHDLN RTFTSSFLNS RPTPDDPYEV TRARELNQLL GPKASGQAFD FVLDLHNTTA
   121  NMGTCLIAKS SHEVFAMHLC RHLQLQYPEL SCQVFLYQRS GEESYNLDSV AKNGLGLELG
   181  PQPQGVLRAD IFSRMRTLVA TVLDFIELFN QGTAFPAFEM EAYRPVGVVD FPRTEAGHLA
   241  GTVHPQLQDR DFQPLQPGAP IFQMFSGEDL LYEGESTVYP VFINEAAYYE KGVAFVQTEK
   301  FTFTVPAMPA LTPAPSPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

duodenum: 73 nTPM
small intestine: 67 nTPM
kidney: 55 nTPM
liver: 32 nTPM
pancreas: 21 nTPM
stomach: 11 nTPM

Single-cell type

enterocytes: 231 nCPM
epididymal efferent duct absorptive cells: 63 nCPM
microglia: 51 nCPM
goblet cells: 50 nCPM
thymocytes: 25 nCPM
gastric chief cells: 24 nCPM

Immune cell

non-classical monocyte: 34 nTPM
plasmacytoid DC: 8.7 nTPM
intermediate monocyte: 7.6 nTPM
NK-cell: 3.9 nTPM
myeloid DC: 3.8 nTPM
total PBMC: 1.9 nTPM

Brain region

spinal cord: 9.4 nTPM
medulla oblongata: 8.4 nTPM
hypothalamus: 8 nTPM
thalamus: 8 nTPM
white matter: 7.6 nTPM
pons: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACY3 as an antibody target. Whether an autoantibody or antibody against ACY3 could matter depends on whether native ACY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACY3 is annotated at the cell surface, where native ACY3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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