Seroatlas · Human Serome Atlas

ACRV1

Acrosomal protein SP-10

Also known as: ASPX_HUMAN, D11S4365, SP-10, SPACA2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P26436
Gene: ACRV1
Ensembl: ENSG00000134940
Chromosome: 11
Canonical length: 265 aa
Protein class: Predicted secreted proteins
Subcellular location: Acrosome
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>P26436|ACRV1
     1  MNRFLLLMSL YLLGSARGTS SQPNELSGSI DHQTSVQQLP GEFFSLENPS DAEALYETSS
    61  GLNTLSEHGS SEHGSSKHTV AEHTSGEHAE SEHASGEPAA TEHAEGEHTV GEQPSGEQPS
   121  GEHLSGEQPL SELESGEQPS DEQPSGEHGS GEQPSGEQAS GEQPSGEHAS GEQASGAPIS
   181  STSTGTILNC YTCAYMNDQG KCLRGEGTCI TQNSQQCMLK KIFEGGKLQF MVQGCENMCP
   241  SMNLFSHGTR MQIICCRNQS FCNKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACRV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

testis: 111 nTPM
epididymis: 3.3 nTPM
basal ganglia: 2.3 nTPM
cerebral cortex: 1.6 nTPM
amygdala: 1.3 nTPM
hippocampal formation: 1.2 nTPM

Single-cell type

early spermatids: 1,056 nCPM
late primary spermatocytes: 446 nCPM
late spermatids: 332 nCPM
sertoli cells: 9.1 nCPM
pdcs: 4.6 nCPM
early primary spermatocytes: 4 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 2.2 nTPM
basal ganglia: 2 nTPM
hypothalamus: 1.8 nTPM
white matter: 1.5 nTPM
amygdala: 1.3 nTPM
pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spermatogenesis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACRV1 as an antibody target. Whether an autoantibody or antibody against ACRV1 could matter depends on whether native ACRV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACRV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACRV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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