Seroatlas · Human Serome Atlas

ACRBP

Acrosin-binding protein

Also known as: ACRBP_HUMAN, CT23, OY-TES-1, SP32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEB7
Gene: ACRBP
Ensembl: ENSG00000111644
Chromosome: 12
Canonical length: 543 aa
Protein class: Predicted secreted proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q8NEB7|ACRBP
     1  MRKPAAGFLP SLLKVLLLPL APAAAQDSTQ ASTPGSPLSP TEYERFFALL TPTWKAETTC
    61  RLRATHGCRN PTLVQLDQYE NHGLVPDGAV CSNLPYASWF ESFCQFTHYR CSNHVYYAKR
   121  VLCSQPVSIL SPNTLKEIEA SAEVSPTTMT SPISPHFTVT ERQTFQPWPE RLSNNVEELL
   181  QSSLSLGGQE QAPEHKQEQG VEHRQEPTQE HKQEEGQKQE EQEEEQEEEG KQEEGQGTKE
   241  GREAVSQLQT DSEPKFHSES LSSNPSSFAP RVREVESTPM IMENIQELIR SAQEIDEMNE
   301  IYDENSYWRN QNPGSLLQLP HTEALLVLCY SIVENTCIIT PTAKAWKYME EEILGFGKSV
   361  CDSLGRRHMS TCALCDFCSL KLEQCHSEAS LQRQQCDTSH KTPFVSPLLA SQSLSIGNQV
   421  GSPESGRFYG LDLYGGLHMD FWCARLATKG CEDVRVSGWL QTEFLSFQDG DFPTKICDTD
   481  YIQYPNYCSF KSQQCLMRNR NRKVSRMRCL QNETYSALSP GKSEDVVLRW SQEFSTLTLG
   541  QFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACRBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 271 nTPM

Expression across tissuesHPA

Tissue

testis: 271 nTPM
epididymis: 13 nTPM
thyroid gland: 13 nTPM
bone marrow: 10 nTPM
spleen: 8.6 nTPM
duodenum: 7.9 nTPM

Single-cell type

platelets: 3,356 nCPM
early spermatids: 1,191 nCPM
late primary spermatocytes: 1,163 nCPM
late spermatids: 939 nCPM
megakaryocytes: 167 nCPM
epididymal principal cells: 96 nCPM

Immune cell

non-classical monocyte: 31 nTPM
myeloid DC: 18 nTPM
intermediate monocyte: 16 nTPM
classical monocyte: 13 nTPM
total PBMC: 11 nTPM
plasmacytoid DC: 4.5 nTPM

Brain region

cerebellum: 3.4 nTPM
white matter: 2.3 nTPM
medulla oblongata: 2.2 nTPM
pons: 2.1 nTPM
basal ganglia: 1.9 nTPM
midbrain: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACRBP.

Disease | ImmuneIEDB

Conditions an epitope on ACRBP was assayed in.

ovarian cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.73
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Kazal domain superfamily
Proacrosin binding sp32
Proacrosin binding protein sp32

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACRBP as an antibody target. Whether an autoantibody or antibody against ACRBP could matter depends on whether native ACRBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACRBP is annotated as secreted, so native ACRBP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ACRBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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