Seroatlas · Human Serome Atlas

ACOXL

Acyl-coenzyme A oxidase-like protein

Also known as: ACOXL_HUMAN, FLJ11042

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUZ1
Gene: ACOXL
Ensembl: ENSG00000153093
Chromosome: 2
Canonical length: 547 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q9NUZ1|ACOXL
     1  MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL
    61  FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID
   121  TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY
   181  KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL
   241  AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV
   301  SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMGYMMENR
   361  ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS
   421  FLAFNMDTVD DLAFLLKAVK FRERVLQRGL VARIYYKVKT KKEDFFHAWN SCLHHVASLS
   481  LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR
   541  IRNQERC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOXL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

lung: 8.7 nTPM
epididymis: 6.8 nTPM
testis: 4.6 nTPM
urinary bladder: 4.3 nTPM
prostate: 3 nTPM
parathyroid gland: 2.7 nTPM

Single-cell type

alveolar cells type 2: 753 nCPM
transitional alveolar cells: 397 nCPM
urothelial cells: 316 nCPM
granulosa cells: 294 nCPM
papillary tip epithelial cells: 256 nCPM
plasma cells: 233 nCPM

Immune cell

neutrophil: 0.8 nTPM
basophil: 0.7 nTPM
classical monocyte: 0.2 nTPM
memory B-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

basal ganglia: 3.3 nTPM
cerebral cortex: 3.3 nTPM
midbrain: 3.3 nTPM
amygdala: 3.2 nTPM
cerebellum: 3.2 nTPM
white matter: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty acid beta-oxidation using acyl-CoA oxidase

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOXL as an antibody target. Whether an autoantibody or antibody against ACOXL could matter depends on whether native ACOXL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOXL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOXL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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