Seroatlas · Human Serome Atlas

ACOT7

Cytosolic acyl coenzyme A thioester hydrolase

Also known as: ACH1, ACT, BACH, BACH_HUMAN, CTE-II, hBACH, LACH1, MGC1126

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00154
Gene: ACOT7
Ensembl: ENSG00000097021
Chromosome: 1
Canonical length: 380 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homohexamer

OverviewNCBI Gene

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>O00154|ACOT7
     1  MKLLARALRL CEFGRQASSR RLVAGQGCVG PRRGCCAPVQ VVGPRADLPP CGACITGRIM
    61  RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE
   121  VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV
   181  YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT
   241  LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS
   301  NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE
   361  GKGRYLQMKA KRQGHAEPQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 141 nTPM
hypothalamus: 131 nTPM
midbrain: 100 nTPM
basal ganglia: 88 nTPM
hippocampal formation: 83 nTPM
amygdala: 78 nTPM

Single-cell type

late spermatids: 214 nCPM
enterocytes: 172 nCPM
mast cells: 162 nCPM
goblet cells: 159 nCPM
cone photoreceptor cells: 145 nCPM
early spermatids: 118 nCPM

Immune cell

NK-cell: 40 nTPM
plasmacytoid DC: 36 nTPM
T-reg: 8.2 nTPM
gdT-cell: 7.4 nTPM
memory CD8 T-cell: 6.2 nTPM
memory CD4 T-cell: 5.8 nTPM

Brain region

pons: 255 nTPM
hypothalamus: 208 nTPM
cerebral cortex: 203 nTPM
medulla oblongata: 168 nTPM
midbrain: 167 nTPM
thalamus: 156 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.76
gnomAD missense Z: 1.98
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

acyl-CoA metabolic process
coenzyme A biosynthetic process
fatty acid catabolic process
medium-chain fatty acid biosynthetic process
medium-chain fatty-acyl-CoA catabolic process
long-chain fatty-acyl-CoA catabolic process
palmitic acid biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT7 as an antibody target. Whether an autoantibody or antibody against ACOT7 could matter depends on whether native ACOT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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