Seroatlas · Human Serome Atlas

ACOT6

Acyl-coenzyme A thioesterase 6

Also known as: ACOT6_HUMAN, C14orf42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3I5F7
Gene: ACOT6
Ensembl: ENSG00000205669
Chromosome: 14
Canonical length: 421 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q3I5F7|ACOT6
     1  MAATLILEPA GRCCWDEPLR IAVRGLAPEQ PVTLRTSLRD EEGALFRAHA RYRADARDEL
    61  DLERAPALGG SFAGLQPMGL LWALEPEKAL VRLVKRDVRT PFAVELEVLD GHDTEPGRLL
   121  CLAQNKRDFL RPGVRREPVR AGPVRAALFL PPDEGPFPGI IDLFGSSRGL CEYRASLLAG
   181  HGFAVLALAY FRFEDLPEDL NDVHLEYFEE AVDFMLQHPK VKGPSIALLG FSKGGDLCLS
   241  MASFLKGITA TVLINACVAN TVAPLHYKDM IIPKLVDDLG KVKITKSGFL TFMDTWSNPL
   301  EEHNHQSLVP LEKAQVPFLF IVGMDDQSWK SEFYAQIASE RLQAHGKERP QIICYPETGH
   361  CIDPPYFPPS RASVHAVLGE AIFYGGEPKA HSKAQVDAWQ QIQTFFHKHL NGKKSVKHSK
   421  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 3.7 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 3.7 nTPM
kidney: 3.4 nTPM
liver: 3 nTPM
adipose tissue: 1.6 nTPM
basal ganglia: 1 nTPM
amygdala: 0.8 nTPM

Single-cell type

cardiomyocytes: 28 nCPM
adipocytes: 22 nCPM
myonuclei: 14 nCPM
hepatocytes: 7.7 nCPM
bergmann glia: 7.2 nCPM
proximal tubule cells: 5.8 nCPM

Immune cell

myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 19 nTPM
cerebral cortex: 13 nTPM
choroid plexus: 13 nTPM
basal ganglia: 11 nTPM
hippocampal formation: 10 nTPM
medulla oblongata: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT6 as an antibody target. Whether an autoantibody or antibody against ACOT6 could matter depends on whether native ACOT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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