Seroatlas · Human Serome Atlas

ACOT2

Acyl-coenzyme A thioesterase 2, mitochondrial

Also known as: ACOT2_HUMAN, Mte1, ZAP128

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49753
Gene: ACOT2
Ensembl: ENSG00000119673
Chromosome: 14
Canonical length: 483 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>P49753|ACOT2
     1  MSNKLLSPHP HSVVLRSEFK MASSPAVLRA SRLYQWSLKS SAQFLGSPQL RQVGQIIRVP
    61  ARMAATLILE PAGRCCWDEP VRIAVRGLAP EQPVTLRASL RDEKGALFQA HARYRADTLG
   121  ELDLERAPAL GGSFAGLEPM GLLWALEPEK PLVRLVKRDV RTPLAVELEV LDGHDPDPGR
   181  LLCQTRHERY FLPPGVRREP VRVGRVRGTL FLPPEPGPFP GIVDMFGTGG GLLEYRASLL
   241  AGKGFAVMAL AYYNYEDLPK TMETLHLEYF EEAMNYLLSH PEVKGPGVGL LGISKGGELC
   301  LSMASFLKGI TAAVVINGSV ANVGGTLHYK GETLPPVGVN RNRIKVTKDG YADIVDVLNS
   361  PLEGPDQKSF IPVERAESTF LFLVGQDDHN WKSEFYANEA CKRLQAHGRR KPQIICYPET
   421  GHYIEPPYFP LCRASLHALV GSPIIWGGEP RAHAMAQVDA WKQLQTFFHK HLGGHEGTIP
   481  SKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

liver: 115 nTPM
skeletal muscle: 107 nTPM
heart muscle: 90 nTPM
adipose tissue: 87 nTPM
breast: 48 nTPM
tongue: 47 nTPM

Single-cell type

cardiomyocytes: 54 nCPM
epididymal efferent duct absorptive cells: 52 nCPM
epididymal principal cells: 41 nCPM
megakaryocytes: 37 nCPM
adipocytes: 36 nCPM
epididymal efferent duct ciliated cells: 35 nCPM

Immune cell

T-reg: 31 nTPM
gdT-cell: 22 nTPM
myeloid DC: 22 nTPM
memory CD4 T-cell: 20 nTPM
naive CD8 T-cell: 20 nTPM
naive CD4 T-cell: 18 nTPM

Brain region

thalamus: 25 nTPM
choroid plexus: 23 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 18 nTPM
hippocampal formation: 18 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.7
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT2 as an antibody target. Whether an autoantibody or antibody against ACOT2 could matter depends on whether native ACOT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...