Seroatlas · Human Serome Atlas

ACOT11

Acyl-coenzyme A thioesterase 11

Also known as: ACO11_HUMAN, BFIT, BFIT1, KIAA0707, STARD14, THEA, THEM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXI4
Gene
ACOT11
Ensembl
ENSG00000162390
Chromosome
1
Canonical length
607 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>Q8WXI4|ACOT11
     1  MIQNVGNHLR RGLASVFSNR TSRKSALRAG NDSAMADGEG YRNPTEVQMS QLVLPCHTNQ
    61  RGELSVGQLL KWIDTTACLS AERHAGCPCV TASMDDIYFE HTISVGQVVN IKAKVNRAFN
   121  SSMEVGIQVA SEDLCSEKQW NVCKALATFV ARREITKVKL KQITPRTEEE KMEHSVAAER
   181  RRMRLVYADT IKDLLANCAI QGDLESRDCS RMVPAEKTRV ESVELVLPPH ANHQGNTFGG
   241  QIMAWMENVA TIAASRLCRA HPTLKAIEMF HFRGPSQVGD RLVLKAIVNN AFKHSMEVGV
   301  CVEAYRQEAE THRRHINSAF MTFVVLDADD QPQLLPWIRP QPGDGERRYR EASARKKIRL
   361  DRKYIVSCKQ TEVPLSVPWD PSNQVYLSYN NVSSLKMLVA KDNWVLSSEI SQVRLYTLED
   421  DKFLSFHMEM VVHVDAAQAF LLLSDLRQRP EWDKHYRSVE LVQQVDEDDA IYHVTSPALG
   481  GHTKPQDFVI LASRRKPCDN GDPYVIALRS VTLPTHRETP EYRRGETLCS GFCLWREGDQ
   541  LTKCCWVRVS LTELVSASGF YSWGLESRSK GRRSDGWNGK LAGGHLSTLK AIPVAKINSR
   601  FGYLQDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACOT11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 32 nTPM
  • heart muscle: 29 nTPM
  • small intestine: 26 nTPM
  • choroid plexus: 26 nTPM
  • kidney: 21 nTPM
  • parathyroid gland: 20 nTPM

Single-cell type

  • choroid plexus epithelial cells: 641 nCPM
  • myonuclei: 491 nCPM
  • thyrotrophs: 406 nCPM
  • somatotrophs: 322 nCPM
  • astrocytes: 317 nCPM
  • ependymal cells: 295 nCPM

Immune cell

  • eosinophil: 4.5 nTPM
  • neutrophil: 1.1 nTPM
  • basophil: 1 nTPM
  • classical monocyte: 0.5 nTPM
  • myeloid DC: 0.5 nTPM
  • non-classical monocyte: 0.4 nTPM

Brain region

  • choroid plexus: 115 nTPM
  • midbrain: 47 nTPM
  • thalamus: 37 nTPM
  • cerebellum: 36 nTPM
  • medulla oblongata: 36 nTPM
  • pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACOT11 as an antibody target. Whether an autoantibody or antibody against ACOT11 could matter depends on whether native ACOT11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACOT11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACOT11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACOT11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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