Seroatlas · Human Serome Atlas

ACKR2

Atypical chemokine receptor 2

Also known as: ACKR2_HUMAN, CCBP2, CCR10, CCR9, CMKBR9, D6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00590
Gene
ACKR2
Ensembl
ENSG00000144648
Chromosome
3
Canonical length
384 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>O00590|ACKR2
     1  MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP VFYSLIFVLG
    61  LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP FWGISVAWHW VFGSFLCKMV
   121  STLYTINFYS GIFFISCMSL DKYLEIVHAQ PYHRLRTRAK SLLLATIVWA VSLAVSIPDM
   181  VFVQTHENPK GVWNCHADFG GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL
   241  RPAGQGRALK IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI
   301  AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES SILTAQEEMT
   361  GMNDLGERQS ENYPNKEDVG NKSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACKR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 15 nTPM
  • liver: 8.8 nTPM
  • adipose tissue: 6.2 nTPM
  • breast: 2.8 nTPM
  • thyroid gland: 2.7 nTPM
  • epididymis: 2.6 nTPM

Single-cell type

  • enterocytes: 11 nCPM
  • adrenal medulla cells: 11 nCPM
  • colonocytes: 9.5 nCPM
  • undifferentiated spermatogonia: 9.4 nCPM
  • extravillous trophoblasts: 9.3 nCPM
  • ependymal cells: 7.1 nCPM

Immune cell

  • eosinophil: 3.8 nTPM
  • NK-cell: 1 nTPM
  • basophil: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • midbrain: 8.3 nTPM
  • medulla oblongata: 8 nTPM
  • amygdala: 7.8 nTPM
  • cerebellum: 7.7 nTPM
  • pons: 7.7 nTPM
  • white matter: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.47
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACKR2 as an antibody target. Whether an autoantibody or antibody against ACKR2 could matter depends on whether native ACKR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACKR2 is annotated at the cell surface, where native ACKR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACKR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACKR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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