Seroatlas · Human Serome Atlas

ACKR1

Atypical chemokine receptor 1

Also known as: ACKR1_HUMAN, CCBP1, CD234, DARC, Dfy, FY, GPD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16570
Gene
ACKR1
Ensembl
ENSG00000213088
Chromosome
1
Canonical length
336 aa
Protein class
Blood group antigen proteins, CD markers, G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q16570|ACKR1
     1  MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS
    61  ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL
   121  GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL
   181  TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG
   241  PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
   301  PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACKR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
388 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 388 nTPM
  • breast: 337 nTPM
  • blood vessel: 176 nTPM
  • lung: 175 nTPM
  • fallopian tube: 160 nTPM
  • vagina: 139 nTPM

Single-cell type

  • vascular endothelial cells: 896 nCPM
  • retinal bipolar cells: 55 nCPM
  • lymphatic endothelial cells: 43 nCPM
  • thymic myoid cells: 26 nCPM
  • erythrocyte progenitors: 22 nCPM
  • salivary myoepithelial cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 47 nTPM
  • cerebral cortex: 32 nTPM
  • spinal cord: 28 nTPM
  • pons: 23 nTPM
  • white matter: 21 nTPM
  • choroid plexus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACKR1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE
  • White blood cell count quantitative trait locus 1
  • Resistance to Plasmodium vivax infection

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Duffy antigen/chemokine receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACKR1 as an antibody target. Whether an autoantibody or antibody against ACKR1 could matter depends on whether native ACKR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACKR1 is annotated at the cell surface, where native ACKR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACKR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACKR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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