Seroatlas · Human Serome Atlas

ACER3

Alkaline ceramidase 3

Also known as: ACER3_HUMAN, APHC, FLJ11238, PHCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUN7
Gene
ACER3
Ensembl
ENSG00000078124
Chromosome
11
Canonical length
267 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

Enables N-acylsphingosine amidohydrolase activity; calcium ion binding activity; and zinc ion binding activity. Involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. Biomarker of hepatocellular carcinoma and metabolic dysfunction-associated steatohepatitis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

267 residues, UniProt reviewed canonical sequence.

>Q9NUN7|ACER3
     1  MAPAADREGY WGPTTSTLDW CEENYSVTWY IAEFWNTVSN LIMIIPPMFG AVQSVRDGLE
    61  KRYIASYLAL TVVGMGSWCF HMTLKYEMQL LDELPMIYSC CIFVYCMFEC FKIKNSVNYH
   121  LLFTLVLFSL IVTTVYLKVK EPIFHQVMYG MLVFTLVLRS IYIVTWVYPW LRGLGYTSLG
   181  IFLLGFLFWN IDNIFCESLR NFRKKVPPII GITTQFHAWW HILTGLGSYL HILFSLYTRT
   241  LYLRYRPKVK FLFGIWPVIL FEPLRKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 13 nTPM
  • adipose tissue: 10 nTPM
  • midbrain: 9 nTPM
  • hippocampal formation: 8 nTPM
  • cerebral cortex: 6.9 nTPM
  • lung: 6.3 nTPM

Single-cell type

  • mast cells: 568 nCPM
  • oligodendrocytes: 401 nCPM
  • neutrophils: 361 nCPM
  • neutrophil progenitors: 337 nCPM
  • adipocytes: 304 nCPM
  • esophageal apical cells: 278 nCPM

Immune cell

  • myeloid DC: 4.5 nTPM
  • classical monocyte: 4.3 nTPM
  • intermediate monocyte: 3 nTPM
  • eosinophil: 2.5 nTPM
  • non-classical monocyte: 2.4 nTPM
  • total PBMC: 1.6 nTPM

Brain region

  • white matter: 20 nTPM
  • pons: 15 nTPM
  • medulla oblongata: 14 nTPM
  • hypothalamus: 14 nTPM
  • cerebellum: 14 nTPM
  • spinal cord: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACER3.

Disease | AllUniProt

Conditions ACER3 is implicated in, by any mechanism.

  • Leukodystrophy, progressive, early childhood-onset (PLDECO) MIM:617762

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 126 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.87
gnomAD missense Z
1.8
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACER3 as an antibody target. Whether an autoantibody or antibody against ACER3 could matter depends on whether native ACER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACER3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACER3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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