Seroatlas · Human Serome Atlas

ACER2

Alkaline ceramidase 2

Also known as: ACER2_HUMAN, ALKCDase2, ASAH3L, FLJ41587

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5QJU3
Gene: ACER2
Ensembl: ENSG00000177076
Chromosome: 9
Canonical length: 275 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q5QJU3|ACER2
     1  MGAPHWWDQL QAGSSEVDWC EDNYTIVPAI AEFYNTISNV LFFILPPICM CLFRQYATCF
    61  NSGIYLIWTL LVVVGIGSVY FHATLSFLGQ MLDELAVLWV LMCALAMWFP RRYLPKIFRN
   121  DRGRFKVVVS VLSAVTTCLA FVKPAINNIS LMTLGVPCTA LLIAELKRCD NMRVFKLGLF
   181  SGLWWTLALF CWISDRAFCE LLSSFNFPYL HCMWHILICL AAYLGCVCFA YFDAASEIPE
   241  QGPVIKFWPN EKWAFIGVPY VSLLCANKKS SVKIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

stomach: 58 nTPM
urinary bladder: 37 nTPM
placenta: 9.1 nTPM
adipose tissue: 7.2 nTPM
pancreas: 6.4 nTPM
breast: 5.5 nTPM

Single-cell type

urothelial cells: 1,314 nCPM
papillary tip epithelial cells: 771 nCPM
foveolar cells: 749 nCPM
prostatic club cells: 375 nCPM
prostatic hillock cells: 331 nCPM
syncytiotrophoblasts: 242 nCPM

Immune cell

intermediate monocyte: 0.5 nTPM
naive CD4 T-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

thalamus: 14 nTPM
cerebral cortex: 12 nTPM
amygdala: 11 nTPM
pons: 11 nTPM
hippocampal formation: 11 nTPM
white matter: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.04
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACER2 as an antibody target. Whether an autoantibody or antibody against ACER2 could matter depends on whether native ACER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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