Seroatlas · Human Serome Atlas

ACCSL

Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2

Also known as: 1A1L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4AC99
Gene: ACCSL
Ensembl: ENSG00000205126
Chromosome: 11
Canonical length: 568 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q4AC99|ACCSL
     1  MSHRSDTLPV PSGQRRGRVP RDHSIYTQLL EITLHLQQAM TEHFVQLTSR QGLSLEERRH
    61  TEAICEHEAL LSRLICRMIN LLQSGAASGL ELQVPLPSED SRGDVRYGQR AQLSGQPDPV
   121  PQLSDCEAAF VNRDLSIRGI DISVFYQSSF QDYNAYQKDK YHKDKNTLGF INLGTSENKL
   181  CMDLMTERLQ ESDMNCIEDT LLQYPDWRGQ PFLREEVARF LTYYCRAPTR LDPENVVVLN
   241  GCCSVFCALA MVLCDPGEAF LVPAPFYGGF AFSSRLYAKV ELIPVHLESE VTVTNTHPFQ
   301  LTVDKLEEAL LEARLEGKKV RGLVLINPQN PLGDIYSPDS LMKYLEFAKR YNLHVIIDEI
   361  YMLSVFDESI TFHSILSMKS LPDSNRTHVI WGTSKDFGIS GFRFGALYTH NKEVASAVSA
   421  FGYLHSISGI TQHKLCQLLQ NTEWIDKVYL PTNCYRLREA HKYITAELKA LEIPFHNRSS
   481  GLYVWINLKK YLDPCTFEEE RLLYCRFLDN KLLLSRGKTY MCKEPGWFCL IFADELPRLK
   541  LAMRRFCDVL QEQKEALIVK QLEDAMRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACCSL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

skin: 0.3 nTPM
testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

melanocytes: 10 nCPM
platelets: 5.7 nCPM
early spermatids: 1.5 nCPM
late spermatids: 1.4 nCPM
late primary spermatocytes: 1.3 nCPM
myosatellite cells: 1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
pons: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

amino acid metabolic process

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Pyridoxal phosphate

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACCSL as an antibody target. Whether an autoantibody or antibody against ACCSL could matter depends on whether native ACCSL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACCSL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACCSL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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