Seroatlas · Human Serome Atlas

ACCS

1-aminocyclopropane-1-carboxylate synthase-like protein 1

Also known as: 1A1L1_HUMAN, ACS, PHACS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QU6
Gene: ACCS
Ensembl: ENSG00000110455
Chromosome: 11
Canonical length: 501 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in amino acid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q96QU6|ACCS
     1  MFTLPQKDFR APTTCLGPTC MQDLGSSHGE DLEGECSRKL DQKLPELRGV GDPAMISSDT
    61  SYLSSRGRMI KWFWDSAEEG YRTYHMDEYD EDKNPSGIIN LGTSENKLCF DLLSWRLSQR
   121  DMQRVEPSLL QYADWRGHLF LREEVAKFLS FYCKSPVPLR PENVVVLNGG ASLFSALATV
   181  LCEAGEAFLI PTPYYGAITQ HVCLYGNIRL AYVYLDSEVT GLDTRPFQLT VEKLEMALRE
   241  AHSEGVKVKG LILISPQNPL GDVYSPEELQ EYLVFAKRHR LHVIVDEVYM LSVFEKSVGY
   301  RSVLSLERLP DPQRTHVMWA TSKDFGMSGL RFGTLYTENQ DVATAVASLC RYHGLSGLVQ
   361  YQMAQLLRDR DWINQVYLPE NHARLKAAHT YVSEELRALG IPFLSRGAGF FIWVDLRKYL
   421  PKGTFEEEML LWRRFLDNKV LLSFGKAFEC KEPGWFRFVF SDQVHRLCLG MQRVQQVLAG
   481  KSQVAEDPRP SQSQEPSDQR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACCS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

liver: 18 nTPM
adrenal gland: 17 nTPM
fallopian tube: 15 nTPM
spleen: 13 nTPM
endometrium: 13 nTPM
thyroid gland: 12 nTPM

Single-cell type

platelets: 47 nCPM
choroid plexus epithelial cells: 31 nCPM
sertoli cells: 30 nCPM
fibro-adipogenic progenitors: 28 nCPM
proximal tubule cells: 23 nCPM
microglia: 23 nCPM

Immune cell

eosinophil: 5.7 nTPM
myeloid DC: 4.4 nTPM
plasmacytoid DC: 3.3 nTPM
classical monocyte: 3.1 nTPM
intermediate monocyte: 3.1 nTPM
non-classical monocyte: 2.5 nTPM

Brain region

choroid plexus: 17 nTPM
hypothalamus: 6.6 nTPM
thalamus: 6.6 nTPM
medulla oblongata: 6.2 nTPM
cerebral cortex: 6 nTPM
midbrain: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

amino acid metabolic process

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Pyridoxal phosphate

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACCS as an antibody target. Whether an autoantibody or antibody against ACCS could matter depends on whether native ACCS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACCS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACCS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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