Seroatlas · Human Serome Atlas

ACBD7

Acyl-CoA-binding domain-containing protein 7

Also known as: ACBD7_HUMAN, bA455B2.2, FLJ38219

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6N7
Gene: ACBD7
Ensembl: ENSG00000176244
Chromosome: 10
Canonical length: 88 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Predicted to act upstream of or within several processes, including energy homeostasis; leptin-mediated signaling pathway; and response to food. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

88 residues, UniProt reviewed canonical sequence.

>Q8N6N7|ACBD7
     1  MALQADFDRA AEDVRKLKAR PDDGELKELY GLYKQAIVGD INIACPGMLD LKGKAKWEAW
    61  NLKKGLSTED ATSAYISKAK ELIEKYGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACBD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

amygdala: 70 nTPM
basal ganglia: 66 nTPM
cerebral cortex: 61 nTPM
midbrain: 51 nTPM
hippocampal formation: 38 nTPM
hypothalamus: 32 nTPM

Single-cell type

bergmann glia: 35 nCPM
astrocytes: 33 nCPM
ependymal cells: 16 nCPM
late primary spermatocytes: 16 nCPM
fallopian tube ciliated cells: 15 nCPM
respiratory ciliated cells: 13 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.7 nTPM
plasmacytoid DC: 0.3 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

midbrain: 70 nTPM
cerebral cortex: 69 nTPM
thalamus: 67 nTPM
basal ganglia: 67 nTPM
amygdala: 66 nTPM
medulla oblongata: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0.12
gnomAD missense Z: 0.03
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty acid metabolic process

Molecular functions

fatty-acyl-CoA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Lipid-binding

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACBD7 as an antibody target. Whether an autoantibody or antibody against ACBD7 could matter depends on whether native ACBD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACBD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACBD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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