Seroatlas · Human Serome Atlas

ACADS

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Also known as: ACAD3, ACADS_HUMAN, SCAD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16219
Gene
ACADS
Ensembl
ENSG00000122971
Chromosome
12
Canonical length
412 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Mitochondria,Mid piece,Principal piece,End piece
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>P16219|ACADS
     1  MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE KELFPIAAQV
    61  DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI AMEEISRGCA STGVIMSVNN
   121  SLYLGPILKF GSKEQKQAWV TPFTSGDKIG CFALSEPGNG SDAGAASTTA RAEGDSWVLN
   181  GTKAWITNAW EASAAVVFAS TDRALQNKGI SAFLVPMPTP GLTLGKKEDK LGIRGSSTAN
   241  LIFEDCRIPK DSILGEPGMG FKIAMQTLDM GRIGIASQAL GIAQTALDCA VNYAENRMAF
   301  GAPLTKLQVI QFKLADMALA LESARLLTWR AAMLKDNKKP FIKEAAMAKL AASEAATAIS
   361  HQAIQILGGM GYVTEMPAER HYRDARITEI YEGTSEIQRL VIAGHLLRSY RS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACADS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
254 nTPM

Expression across tissuesHPA

Tissue

  • liver: 254 nTPM
  • skeletal muscle: 161 nTPM
  • heart muscle: 91 nTPM
  • duodenum: 80 nTPM
  • tongue: 75 nTPM
  • colon: 74 nTPM

Single-cell type

  • enterocytes: 386 nCPM
  • colonocytes: 277 nCPM
  • hepatocytes: 241 nCPM
  • enteric transient amplifying cells: 204 nCPM
  • enteric stem cells: 142 nCPM
  • paneth cells: 112 nCPM

Immune cell

  • NK-cell: 20 nTPM
  • intermediate monocyte: 16 nTPM
  • naive CD4 T-cell: 15 nTPM
  • classical monocyte: 15 nTPM
  • T-reg: 15 nTPM
  • naive CD8 T-cell: 14 nTPM

Brain region

  • thalamus: 19 nTPM
  • basal ganglia: 17 nTPM
  • medulla oblongata: 16 nTPM
  • white matter: 16 nTPM
  • midbrain: 15 nTPM
  • spinal cord: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACADS.

Disease | AllUniProt

Conditions ACADS is implicated in, by any mechanism.

  • Acyl-CoA dehydrogenase short-chain deficiency (ACADSD) MIM:201470

Disease | GeneticClinVar

94 pathogenic / likely-pathogenic of 504 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACADS as an antibody target. Whether an autoantibody or antibody against ACADS could matter depends on whether native ACADS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACADS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACADS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACADS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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