Seroatlas · Human Serome Atlas

ACAD10

Acyl-CoA dehydrogenase family member 10

Also known as: ACD10_HUMAN, MGC5601

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6JQN1
Gene
ACAD10
Ensembl
ENSG00000111271
Chromosome
12
Canonical length
1059 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

1059 residues, UniProt reviewed canonical sequence.

>Q6JQN1|ACAD10
     1  MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV
    61  AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD
   121  SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE
   181  SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE
   241  LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGPLELLQ FDHGQSNPTY
   301  YIRLANRDLV LRKKPPGTLL PSAHAIEREF RIMKALANAG VPVPNVLDLC EDSSVIGTPF
   361  YVMEYCPGLI YKDPSLPGLE PSHRRAIYTA MNTVLCKIHS VDLQAVGLED YGKQGDYIPR
   421  QVRTWVKQYR ASETSTIPAM ERLIEWLPLH LPRQQRTTVV HGDFRLDNLV FHPEEPEVLA
   481  VLDWELSTLG DPLADVAYSC LAHYLPSSFP VLRGINDCDL TQLGIPAAEE YFRMYCLQMG
   541  LPPTENWNFY MAFSFFRVAA ILQGVYKRSL TGQASSTYAE QTGKLTEFVS NLAWDFAVKE
   601  GFRVFKEMPF TNPLTRSYHT WARPQSQWCP TGSRSYSSVP EASPAHTSRG GLVISPESLS
   661  PPVRELYHRL KHFMEQRVYP AEPELQSHQA SAARWSPSPL IEDLKEKAKA EGLWNLFLPL
   721  EADPEKKYGA GLTNVEYAHL CELMGTSLYA PEVCNCSAPD TGNMELLVRY GTEAQKARWL
   781  IPLLEGKARS CFAMTEPQVA SSDATNIEAS IREEDSFYVI NGHKWWITGI LDPRCQLCVF
   841  MGKTDPHAPR HRQQSVLLVP MDTPGIKIIR PLTVYGLEDA PGGHGEVRFE HVRVPKENMV
   901  LGPGRGFEIA QGRLGPGRIH HCMRLIGFSE RALALMKARV KSRLAFGKPL VEQGTVLADI
   961  AQSRVEIEQA RLLVLRAAHL MDLAGNKAAA LDIAMIKMVA PSMASRVIDR AIQAFGAAGL
  1021  SSDYPLAQFF TWARALRFAD GPDEVHRATV AKLELKHRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • liver: 21 nTPM
  • kidney: 18 nTPM
  • parathyroid gland: 18 nTPM
  • duodenum: 15 nTPM
  • small intestine: 14 nTPM
  • heart muscle: 14 nTPM

Single-cell type

  • myonuclei: 102 nCPM
  • choroid plexus epithelial cells: 82 nCPM
  • thyrotrophs: 78 nCPM
  • distal convoluted tubule cells: 57 nCPM
  • rod photoreceptor cells: 56 nCPM
  • adipocytes: 53 nCPM

Immune cell

  • non-classical monocyte: 8.7 nTPM
  • basophil: 6.9 nTPM
  • intermediate monocyte: 6.9 nTPM
  • neutrophil: 6.9 nTPM
  • classical monocyte: 6.2 nTPM
  • myeloid DC: 6.1 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • white matter: 23 nTPM
  • cerebellum: 20 nTPM
  • pons: 19 nTPM
  • cerebral cortex: 19 nTPM
  • basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACAD10 as an antibody target. Whether an autoantibody or antibody against ACAD10 could matter depends on whether native ACAD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACAD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACAD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACAD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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