ACAA1

Protein identityUniProt · HPA

UniProt accession

P09110

Gene

ACAA1

Ensembl

ENSG00000060971

Chromosome

3

Canonical length

424 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Peroxisomes

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>P09110|ACAA1
     1  MQRLQVVLGH LRGPADSGWM PQAAPCLSGA PQASAADVVV VHGRRTAICR AGRGGFKDTT
    61  PDELLSAVMT AVLKDVNLRP EQLGDICVGN VLQPGAGAIM ARIAQFLSDI PETVPLSTVN
   121  RQCSSGLQAV ASIAGGIRNG SYDIGMACGV ESMSLADRGN PGNITSRLME KEKARDCLIP
   181  MGITSENVAE RFGISREKQD TFALASQQKA ARAQSKGCFQ AEIVPVTTTV HDDKGTKRSI
   241  TVTQDEGIRP STTMEGLAKL KPAFKKDGST TAGNSSQVSD GAAAILLARR SKAEELGLPI
   301  LGVLRSYAVV GVPPDIMGIG PAYAIPVALQ KAGLTVSDVD IFEINEAFAS QAAYCVEKLR
   361  LPPEKVNPLG GAVALGHPLG CTGARQVITL LNELKRRGKR AYGVVSMCIG TGMGAAAVFE
   421  YPGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACAA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

616 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

1.22

DepMap mean gene effect

0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• alpha-linolenic acid metabolic process
• bile acid metabolic process
• fatty acid beta-oxidation
• fatty acid beta-oxidation using acyl-CoA oxidase
• very long-chain fatty acid metabolic process
• phenylacetate catabolic process

Molecular functions

• acetyl-CoA C-acetyltransferase activity
• acetyl-CoA C-acyltransferase activity
• acetyl-CoA C-myristoyltransferase activity
• long-chain fatty acyl-CoA oxidase activity
• acetate CoA-transferase activity

Cellular components

• cytosol
• extracellular region
• membrane
• peroxisomal matrix
• peroxisome
• specific granule lumen

Protein domainsUniProt · Pfam · InterPro

• Thiolase
• Thiolase-like
• Thiolase, active site
• Thiolase, conserved site
• Thiolase, acyl-enzyme intermediate active site
• Thiolase, N-terminal
• Thiolase, C-terminal
• Thiolase, N-terminal domain
• Thiolase, C-terminal domain
• 3-ketoacyl-CoA thiolase-like

KeywordsUniProt

• Acyltransferase
• Fatty acid metabolism
• Lipid metabolism
• Peroxisome
• Phosphoprotein
• Transferase
• Transit peptide