Seroatlas · Human Serome Atlas

ABRACL

Costars family protein ABRACL

Also known as: ABRAL_HUMAN, C6orf115, Costars, HSPC280, PRO2013

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P1F3
Gene
ABRACL
Ensembl
ENSG00000146386
Chromosome
6
Canonical length
81 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of actin filament-based process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

81 residues, UniProt reviewed canonical sequence.

>Q9P1F3|ABRACL
     1  MNVDHEVNLL VEEIHRLGSK NADGKLSVKF GVLFRDDKCA NLFEALVGTL KAAKRRKIVT
    61  YPGELLLQGV HDDVDIILLQ D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABRACL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 130 nTPM
  • epididymis: 129 nTPM
  • lymph node: 115 nTPM
  • colon: 89 nTPM
  • bone marrow: 83 nTPM
  • tonsil: 82 nTPM

Single-cell type

  • megakaryocytes: 933 nCPM
  • esophageal apical cells: 500 nCPM
  • hofbauer cells: 470 nCPM
  • kupffer cells: 440 nCPM
  • extravillous trophoblasts: 298 nCPM
  • hepatocytes: 292 nCPM

Immune cell

  • non-classical monocyte: 517 nTPM
  • total PBMC: 348 nTPM
  • intermediate monocyte: 335 nTPM
  • T-reg: 261 nTPM
  • memory CD4 T-cell: 260 nTPM
  • MAIT T-cell: 253 nTPM

Brain region

  • hippocampal formation: 15 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 11 nTPM
  • hypothalamus: 9.9 nTPM
  • pons: 9.8 nTPM
  • white matter: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0.24
gnomAD missense Z
0.41
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABRACL as an antibody target. Whether an autoantibody or antibody against ABRACL could matter depends on whether native ABRACL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABRACL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABRACL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABRACL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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