Seroatlas · Human Serome Atlas

ABO

Histo-blood group ABO system transferase

Also known as: BGAT_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16442
Gene
ABO
Canonical length
354 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for ABO in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>P16442|ABO
     1  MAEVLRTLAG KPKCHALRPM ILFLIMLVLV LFGYGVLSPR SLMPGSLERG FCMAVREPDH
    61  LQRVSLPRMV YPQPKVLTPC RKDVLVVTPW LAPIVWEGTF NIDILNEQFR LQNTTIGLTV
   121  FAIKKYVAFL KLFLETAEKH FMVGHRVHYY VFTDQPAAVP RVTLGTGRQL SVLEVRAYKR
   181  WQDVSMRRME MISDFCERRF LSEVDYLVCV DVDMEFRDHV GVEILTPLFG TLHPGFYGSS
   241  REAFTYERRP QSQAYIPKDE GDFYYLGGFF GGSVQEVQRL TRACHQAMMV DQANGIEAVW
   301  HDESHLNKYL LRHKPTKVLS PEYLWDQQLL GWPAVLRKLR FTAVPKNHQA VRNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 14 nTPM
  • small intestine: 13 nTPM
  • fallopian tube: 9 nTPM
  • thyroid gland: 9 nTPM
  • esophagus: 6.8 nTPM
  • colon: 6.7 nTPM

Single-cell type

  • renal collecting duct principal cells: 120 nCPM
  • papillary tip epithelial cells: 113 nCPM
  • renal connecting tubule cells: 102 nCPM
  • renal collecting duct intercalated cells: 89 nCPM
  • loop of henle epithelial cells: 62 nCPM
  • proximal tubule cells: 59 nCPM

Immune cell

  • eosinophil: 2.1 nTPM
  • naive B-cell: 2.1 nTPM
  • total PBMC: 1.5 nTPM
  • basophil: 0.7 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • neutrophil: 0.6 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebral cortex: 17 nTPM
  • hypothalamus: 15 nTPM
  • white matter: 15 nTPM
  • cerebellum: 14 nTPM
  • basal ganglia: 14 nTPM

ReferencesPubMed · IEDB

Publications for ABO from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

11 publications

Show 6 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABO as an antibody target. Whether an autoantibody or antibody against ABO could matter depends on whether native ABO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABO is annotated as secreted, so native ABO circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ABO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABO. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...