Seroatlas · Human Serome Atlas

ABHD6

Monoacylglycerol lipase ABHD6

Also known as: ABHD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BV23
Gene: ABHD6
Ensembl: ENSG00000163686
Chromosome: 3
Canonical length: 337 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables monoacylglycerol lipase activity. Involved in acylglycerol catabolic process. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9BV23|ABHD6
     1  MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF
    61  CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS
   121  IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST
   181  DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN
   241  NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL
   301  LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

liver: 61 nTPM
small intestine: 49 nTPM
duodenum: 37 nTPM
spinal cord: 36 nTPM
kidney: 33 nTPM
spleen: 33 nTPM

Single-cell type

proximal tubule cells: 159 nCPM
corticotrophs: 152 nCPM
enterocytes: 137 nCPM
oligodendrocytes: 118 nCPM
hepatocytes: 93 nCPM
lactotrophs: 85 nCPM

Immune cell

intermediate monocyte: 7.4 nTPM
plasmacytoid DC: 5.4 nTPM
non-classical monocyte: 5.2 nTPM
memory B-cell: 3.7 nTPM
myeloid DC: 3.7 nTPM
naive B-cell: 2.5 nTPM

Brain region

white matter: 88 nTPM
thalamus: 61 nTPM
cerebellum: 59 nTPM
basal ganglia: 57 nTPM
midbrain: 54 nTPM
medulla oblongata: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD6 as an antibody target. Whether an autoantibody or antibody against ABHD6 could matter depends on whether native ABHD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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